open access

Vol 20, No 3 (2014)
Original papers
Published online: 2014-12-10

The effect of erythropoietin on endosalpingeal karyorrhexis during ischemia reperfusion injury in rats

Constantinos Tsompos, Constantinos Panoulis, Konstantinos Toutouzas, George Agrogiannis, Efstratios Patsouris, George Zografos, Apostolos Papalois
Acta Angiologica 2014;20(3):119-123.

open access

Vol 20, No 3 (2014)
Original papers
Published online: 2014-12-10

Abstract

Introduction. The aim of this experiment was to study the effects of the antioxidant drug “U-74389G” on rat model, particularly in ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean endosalpingeal karyorrhexis (EK) lesions.

Material and methods. 40 rats were used of mean weight 247.7 g. EK was evaluated 60 min after reperfusion for groups A and C and 120 min after reperfusion for groups B and D. Groups A and B without the drug but C and D with erythropoietin administration.

Results. Results were that erythropoietin administration kept non-significantly increased the EK scores by 0.1 (–0.0393284–0.2393284) (p = 0.1544). This finding was in accordance with the results of Wilcoxon signed-rank test (p = 0.1573). Reperfusion time non-significantly decreased the EK scores by 0.1 (–0.2393284–0.0393284) (p = 0.1544), approximately in accordance with the increased EK score by 0.1 (–0.2440518–0.0440518) of Wilcoxon signed-rank test (p = 0.1573). However, Epo administration and reperfusion time together kept non-significantly increased the EK scores by 0.0181818 (–0.0679319–0.1042955) (p = 0.6715).

Conclusions. Results of this study indicate that Epo administration kept non-significantly increased the EK scores. Perhaps, a longer study time than 2 hours may provide more significant effects.

Keywords

erythropoietin, endosalpingeal karyorrhexis, reperfusion

About this article
Title

The effect of erythropoietin on endosalpingeal karyorrhexis during ischemia reperfusion injury in rats

Journal

Acta Angiologica

Issue

Vol 20, No 3 (2014)

Pages

119-123

Published online

2014-12-10

Bibliographic record

Acta Angiologica 2014;20(3):119-123.

Keywords

erythropoietin
endosalpingeal karyorrhexis
reperfusion

Authors

Constantinos Tsompos
Constantinos Panoulis
Konstantinos Toutouzas
George Agrogiannis
Efstratios Patsouris
George Zografos
Apostolos Papalois

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl