open access

Vol 20, No 1 (2014)
Artykuły
Published online: 2014-04-24
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Circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) in selected diseases

Krzysztof Scheller, Jacek Wroński, Marcin Feldo
Acta Angiologica 2014;20(1):1-18.

open access

Vol 20, No 1 (2014)
Artykuły
Published online: 2014-04-24

Abstract

Circulating endothelial cells (CECs) are exfoliated endothelial cells which have penetrated into peripheral blood. CECs can be isolated from peripheral blood and counted. The elevated level of these cells, which occurs in a variety of diseases and leads to blood vessels damage, is a new and promosing diagnostic and prognostic marker. The number of identified diseases that raise endothelial cell levels in peripheral blood has been constantly increasing. Circulating endothelial precursor cells (CEPCs) come from the bone marrow, differ from CECs in terms of phenotypic features, and participate in postnatal neovascularization and reconstruction of the damaged endothelium. CEPCs are released from the bone marrow in response to tissue ischemia and act as a substrate for neoangiogenesis there. The aim of this study is to present the issue of CECs and CEPCs, their immunological characteristics and methods of determination, as well as selected diseases and clinical conditions in which the level of these cells is connected with their manifestation and/or exacerbation.

Abstract

Circulating endothelial cells (CECs) are exfoliated endothelial cells which have penetrated into peripheral blood. CECs can be isolated from peripheral blood and counted. The elevated level of these cells, which occurs in a variety of diseases and leads to blood vessels damage, is a new and promosing diagnostic and prognostic marker. The number of identified diseases that raise endothelial cell levels in peripheral blood has been constantly increasing. Circulating endothelial precursor cells (CEPCs) come from the bone marrow, differ from CECs in terms of phenotypic features, and participate in postnatal neovascularization and reconstruction of the damaged endothelium. CEPCs are released from the bone marrow in response to tissue ischemia and act as a substrate for neoangiogenesis there. The aim of this study is to present the issue of CECs and CEPCs, their immunological characteristics and methods of determination, as well as selected diseases and clinical conditions in which the level of these cells is connected with their manifestation and/or exacerbation.

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Keywords

circulating endothelial cells, circulating endothelial precursors cells, ischemic diseases

About this article
Title

Circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) in selected diseases

Journal

Acta Angiologica

Issue

Vol 20, No 1 (2014)

Pages

1-18

Published online

2014-04-24

Bibliographic record

Acta Angiologica 2014;20(1):1-18.

Keywords

circulating endothelial cells
circulating endothelial precursors cells
ischemic diseases

Authors

Krzysztof Scheller
Jacek Wroński
Marcin Feldo

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