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Circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) in selected diseases
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Abstract
Circulating endothelial cells (CECs) are exfoliated endothelial cells which have penetrated into peripheral blood. CECs can be isolated from peripheral blood and counted. The elevated level of these cells, which occurs in a variety of diseases and leads to blood vessels damage, is a new and promosing diagnostic and prognostic marker. The number of identified diseases that raise endothelial cell levels in peripheral blood has been constantly increasing. Circulating endothelial precursor cells (CEPCs) come from the bone marrow, differ from CECs in terms of phenotypic features, and participate in postnatal neovascularization and reconstruction of the damaged endothelium. CEPCs are released from the bone marrow in response to tissue ischemia and act as a substrate for neoangiogenesis there. The aim of this study is to present the issue of CECs and CEPCs, their immunological characteristics and methods of determination, as well as selected diseases and clinical conditions in which the level of these cells is connected with their manifestation and/or exacerbation.
Abstract
Circulating endothelial cells (CECs) are exfoliated endothelial cells which have penetrated into peripheral blood. CECs can be isolated from peripheral blood and counted. The elevated level of these cells, which occurs in a variety of diseases and leads to blood vessels damage, is a new and promosing diagnostic and prognostic marker. The number of identified diseases that raise endothelial cell levels in peripheral blood has been constantly increasing. Circulating endothelial precursor cells (CEPCs) come from the bone marrow, differ from CECs in terms of phenotypic features, and participate in postnatal neovascularization and reconstruction of the damaged endothelium. CEPCs are released from the bone marrow in response to tissue ischemia and act as a substrate for neoangiogenesis there. The aim of this study is to present the issue of CECs and CEPCs, their immunological characteristics and methods of determination, as well as selected diseases and clinical conditions in which the level of these cells is connected with their manifestation and/or exacerbation.
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Keywords
circulating endothelial cells, circulating endothelial precursors cells, ischemic diseases
About this articleTitle
Circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) in selected diseases
Journal
Issue
Pages
1-18
Published online
2014-04-24
Page views
941
Article views/downloads
4400
DOI
10.5603/aa.36098
Bibliographic record
Acta Angiologica 2014;20(1):1-18.
Keywords
circulating endothelial cells
circulating endothelial precursors cells
ischemic diseases
Authors
Krzysztof Scheller
Jacek Wroński
Marcin Feldo