open access

Vol 18, No 4 (2012)
Original papers
Published online: 2013-01-01
Get Citation

Matrix Metalloproteinase-13 (–77A>G) gene polymorphism is not a susceptibility factor of abdominal aortic aneurysm or aortoiliac occlusive disease in the Polish population

Aleksandra Korcz, Oliwia Zakerska, Katarzyna Pawlaczyk, Daria Szypura-Ratajczak, Marta Molińska-Glura, Grzegorz Oszkinis, Ryszard Słomski, Marcin Gabriel
Acta Angiologica 2012;18(4):148-156.

open access

Vol 18, No 4 (2012)
Original papers
Published online: 2013-01-01

Abstract

Abdominal aortic aneurysm (AAA) and aortoiliac occlusive disease (AIOD) are common vascular diseases with
both genetic and environmental risk factors involved. Matrix metalloproteinases (MMPs) play a major role in
the remodelling of the extracellular matrix of aorta, and their contribution to the pathogenesis of abdominal
aortic aneurysm is unquestionable. The purpose of this study was to examine the role of MMP13 (–77A>G)
gene polymorphism in the development of abdominal aortic aneurysm (AAA) or aortoiliac occlusive disease
(AIOD) in the Polish population. We investigated 925 individuals in 3 groups: AAA (n = 300), AIOD (n = 312),
and control (n = 313). The MMP13 (–77A>G) genotyping analysis was performed by PCR–RFLP methods
and gel electrophoresis. The MMP13 (–77A>G) genotype distribution and allele frequencies were consistent
with the Hardy-Weinberg equilibrium. No significant differences in genotype distribution and allele frequencies
between patients with the AAA or AIOD and the control group were observed. There were also no significant
differences in MMP13 (–77A>G) genotype distribution and allele frequencies between the study groups in
regard to gender, hypertension, myocardial infarction, or other risk factors. The results of our study indicate
that MMP13 (–77A>G) gene polymorphism is a susceptibility factor neither of abdominal aortic aneurysm
nor aortoiliac occlusive disease in the Polish population.

Abstract

Abdominal aortic aneurysm (AAA) and aortoiliac occlusive disease (AIOD) are common vascular diseases with
both genetic and environmental risk factors involved. Matrix metalloproteinases (MMPs) play a major role in
the remodelling of the extracellular matrix of aorta, and their contribution to the pathogenesis of abdominal
aortic aneurysm is unquestionable. The purpose of this study was to examine the role of MMP13 (–77A>G)
gene polymorphism in the development of abdominal aortic aneurysm (AAA) or aortoiliac occlusive disease
(AIOD) in the Polish population. We investigated 925 individuals in 3 groups: AAA (n = 300), AIOD (n = 312),
and control (n = 313). The MMP13 (–77A>G) genotyping analysis was performed by PCR–RFLP methods
and gel electrophoresis. The MMP13 (–77A>G) genotype distribution and allele frequencies were consistent
with the Hardy-Weinberg equilibrium. No significant differences in genotype distribution and allele frequencies
between patients with the AAA or AIOD and the control group were observed. There were also no significant
differences in MMP13 (–77A>G) genotype distribution and allele frequencies between the study groups in
regard to gender, hypertension, myocardial infarction, or other risk factors. The results of our study indicate
that MMP13 (–77A>G) gene polymorphism is a susceptibility factor neither of abdominal aortic aneurysm
nor aortoiliac occlusive disease in the Polish population.
Get Citation

Keywords

AAA; abdominal aortic aneurysm; AIOD; aortoiliac occlusive disease; gene polymorphism; MMP13; susceptibility factor

About this article
Title

Matrix Metalloproteinase-13 (–77A>G) gene polymorphism is not a susceptibility factor of abdominal aortic aneurysm or aortoiliac occlusive disease in the Polish population

Journal

Acta Angiologica

Issue

Vol 18, No 4 (2012)

Pages

148-156

Published online

2013-01-01

Bibliographic record

Acta Angiologica 2012;18(4):148-156.

Keywords

AAA
abdominal aortic aneurysm
AIOD
aortoiliac occlusive disease
gene polymorphism
MMP13
susceptibility factor

Authors

Aleksandra Korcz
Oliwia Zakerska
Katarzyna Pawlaczyk
Daria Szypura-Ratajczak
Marta Molińska-Glura
Grzegorz Oszkinis
Ryszard Słomski
Marcin Gabriel

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl