open access

Vol 18, No 3 (2012)
Miscellanea
Published online: 2012-10-29
Get Citation

Reflections on the causes and treatment of multiple sclerosis

Jacek Stankowski, Jerzy Zwoliński, Wojciech Witkiewicz
Acta Angiologica 2012;18(3):118-123.

open access

Vol 18, No 3 (2012)
Miscellanea
Published online: 2012-10-29

Abstract

Sclerosis multiplex (SM) is considered as a immunologic disease, which pathogenesis still remains unknown
— it is therefore difficult to choose the optimal method of treatment. The aim of this review is to analyze
the vascular theory of pathogenesis of SM and possibilities of new therapeutic options of the disease. Surprising
is the number of common elements both in the vascular theory of SM, and the effects of subarachnoid
haemorrhage. Additionally, in light of current research studies, it apears that responsible for the neurological
detoriation after SAH is not just reactive arterial narrowing, but rather the local inflammatory response
generated by the extravasated blood. It seems to be a logical proposal to use the similar treatment in the
acute MS relapse as the nimodipine treatment for acute neurological deterioration after SAH.

Abstract

Sclerosis multiplex (SM) is considered as a immunologic disease, which pathogenesis still remains unknown
— it is therefore difficult to choose the optimal method of treatment. The aim of this review is to analyze
the vascular theory of pathogenesis of SM and possibilities of new therapeutic options of the disease. Surprising
is the number of common elements both in the vascular theory of SM, and the effects of subarachnoid
haemorrhage. Additionally, in light of current research studies, it apears that responsible for the neurological
detoriation after SAH is not just reactive arterial narrowing, but rather the local inflammatory response
generated by the extravasated blood. It seems to be a logical proposal to use the similar treatment in the
acute MS relapse as the nimodipine treatment for acute neurological deterioration after SAH.
Get Citation

Keywords

sclerosis multiplex, nimodipine, subarachnoid hemorrhage, demyelination, inflammation

About this article
Title

Reflections on the causes and treatment of multiple sclerosis

Journal

Acta Angiologica

Issue

Vol 18, No 3 (2012)

Pages

118-123

Published online

2012-10-29

Bibliographic record

Acta Angiologica 2012;18(3):118-123.

Keywords

sclerosis multiplex
nimodipine
subarachnoid hemorrhage
demyelination
inflammation

Authors

Jacek Stankowski
Jerzy Zwoliński
Wojciech Witkiewicz

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