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Reflections on the causes and treatment of multiple sclerosis
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Abstract
— it is therefore difficult to choose the optimal method of treatment. The aim of this review is to analyze
the vascular theory of pathogenesis of SM and possibilities of new therapeutic options of the disease. Surprising
is the number of common elements both in the vascular theory of SM, and the effects of subarachnoid
haemorrhage. Additionally, in light of current research studies, it apears that responsible for the neurological
detoriation after SAH is not just reactive arterial narrowing, but rather the local inflammatory response
generated by the extravasated blood. It seems to be a logical proposal to use the similar treatment in the
acute MS relapse as the nimodipine treatment for acute neurological deterioration after SAH.
Abstract
— it is therefore difficult to choose the optimal method of treatment. The aim of this review is to analyze
the vascular theory of pathogenesis of SM and possibilities of new therapeutic options of the disease. Surprising
is the number of common elements both in the vascular theory of SM, and the effects of subarachnoid
haemorrhage. Additionally, in light of current research studies, it apears that responsible for the neurological
detoriation after SAH is not just reactive arterial narrowing, but rather the local inflammatory response
generated by the extravasated blood. It seems to be a logical proposal to use the similar treatment in the
acute MS relapse as the nimodipine treatment for acute neurological deterioration after SAH.
Keywords
sclerosis multiplex, nimodipine, subarachnoid hemorrhage, demyelination, inflammation
About this articleTitle
Reflections on the causes and treatment of multiple sclerosis
Journal
Issue
Article type
Other materials agreed with the Editors
Pages
118-123
Published online
2012-10-29
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Bibliographic record
Acta Angiologica 2012;18(3):118-123.
Keywords
sclerosis multiplex
nimodipine
subarachnoid hemorrhage
demyelination
inflammation
Authors
Jacek Stankowski
Jerzy Zwoliński
Wojciech Witkiewicz