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Therapeutic problems in patient with hereditary hemorrhagic teleangiectasia and venous thromboembolic disease
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Abstract
to multiorgan vascular dysplasia, involving teleangiectasias and arteriovenous malformations of the skin, the
nose, lungs, the alimentary tract and the central nervous system. Thromboembolic incidents in patients with
HHT occur rarely, however present serious therapeutic challenge. We present a case of 57-year old male
patient with HHT and lower extremity deep vein thrombosis, complicated with pulmonary embolism in whom
administration of antithrombotic drugs in therapeutic dose resulted in uncontrollable epistaxis. Eventually,
embolization of bleeding vessels enabled the therapy with accurate dosage of anticoagulant drug.
Abstract
to multiorgan vascular dysplasia, involving teleangiectasias and arteriovenous malformations of the skin, the
nose, lungs, the alimentary tract and the central nervous system. Thromboembolic incidents in patients with
HHT occur rarely, however present serious therapeutic challenge. We present a case of 57-year old male
patient with HHT and lower extremity deep vein thrombosis, complicated with pulmonary embolism in whom
administration of antithrombotic drugs in therapeutic dose resulted in uncontrollable epistaxis. Eventually,
embolization of bleeding vessels enabled the therapy with accurate dosage of anticoagulant drug.
Keywords
hemorrhagic teleangiectasia, Rendu-Osler-Weber disease, pulmonary embolism, deep vein thrombosis
About this articleTitle
Therapeutic problems in patient with hereditary hemorrhagic teleangiectasia and venous thromboembolic disease
Journal
Issue
Article type
Research paper
Pages
79-85
Published online
2012-09-10
Bibliographic record
Acta Angiologica 2012;18(2):79-85.
Keywords
hemorrhagic teleangiectasia
Rendu-Osler-Weber disease
pulmonary embolism
deep vein thrombosis
Authors
Rafał Małecki
Weronika Rydel
Anna Stępień
Agnieszka Orchowska-Jędrzejewska
Andrzej Dołyk
Rajmund Adamiec