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Evaluation of insulin-like growth factor I in the varicose vein wall
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Abstract
Material and methods. Walls of varicose veins and varicose veins complicated by thrombophlebitis made up the studied material. Walls of normal saphenous veins, which were harvested from patients with chronic limb ischaemia undergoing infrainguinal by-pass grafting, made up the control material. Contents of IGF-I, IGFBP-3, and IGF-1R in the investigated tissues were evaluated using the ELISA method.
Results. IGF-I content in walls of varicose veins and varicose veins complicated by thrombophlebitis were comparable, and were increased compared to the walls of normal veins. IGFBP-3 content was significantly increased only in the walls of varicose veins complicated by thrombophlebitis. IGF-1R level were increased in the walls of varicose veins compared to the walls normal of veins; whereas, in the course of thrombophlebitis, it was increased compared to the walls of normal veins, as well as uncomplicated varicose veins.
Conclusions. The study results indicate differences in IGF-I, IGFBP-3, and IGF-1R content between walls of healthy veins, varicose veins, and varicose veins complicated by thrombophlebitis.
Acta Angiol 2011; 17, 4: 264–270
Abstract
Material and methods. Walls of varicose veins and varicose veins complicated by thrombophlebitis made up the studied material. Walls of normal saphenous veins, which were harvested from patients with chronic limb ischaemia undergoing infrainguinal by-pass grafting, made up the control material. Contents of IGF-I, IGFBP-3, and IGF-1R in the investigated tissues were evaluated using the ELISA method.
Results. IGF-I content in walls of varicose veins and varicose veins complicated by thrombophlebitis were comparable, and were increased compared to the walls of normal veins. IGFBP-3 content was significantly increased only in the walls of varicose veins complicated by thrombophlebitis. IGF-1R level were increased in the walls of varicose veins compared to the walls normal of veins; whereas, in the course of thrombophlebitis, it was increased compared to the walls of normal veins, as well as uncomplicated varicose veins.
Conclusions. The study results indicate differences in IGF-I, IGFBP-3, and IGF-1R content between walls of healthy veins, varicose veins, and varicose veins complicated by thrombophlebitis.
Acta Angiol 2011; 17, 4: 264–270
Keywords
IGF-I; IGFBP-3; IGF-1R; thrombophlebitis; varicose veins


Title
Evaluation of insulin-like growth factor I in the varicose vein wall
Journal
Issue
Article type
Research paper
Pages
264-270
Published online
2011-12-14
Page views
542
Article views/downloads
1427
Bibliographic record
Acta Angiologica 2011;17(4):264-270.
Keywords
IGF-I
IGFBP-3
IGF-1R
thrombophlebitis
varicose veins
Authors
Radosław Kowalewski
Andrzej Małkowski
Krzysztof Sobolewski
Marek Gacko