dostęp otwarty
The role of metabolites in morphine analgesic effects
Afiliacje- Institute of Experimental and Clinical Medicine, Medical Faculty, University of Rzeszów
dostęp otwarty
Streszczenie
Morphine is metabolized into two main metabolites, morphine-3-glucuronide and morphine-6-glucuronide. Morphine-6-glucuronide is a potent analgesic that is responsible for up to 97% of the analgesic effect. Morphine-3-glucuronide does not bind to opioid receptors and is devoid of any analgesic effect. However, it activates the Toll-like 4 receptors initiating neurogenic inflammation in the central nervous system. This, in turn, is responsible for anti–analgesic and hyperalgesic effects. There are a number of strategies on how to inhibit this pronociceptive effect and finally improve morphine analgesia.
Streszczenie
Morphine is metabolized into two main metabolites, morphine-3-glucuronide and morphine-6-glucuronide. Morphine-6-glucuronide is a potent analgesic that is responsible for up to 97% of the analgesic effect. Morphine-3-glucuronide does not bind to opioid receptors and is devoid of any analgesic effect. However, it activates the Toll-like 4 receptors initiating neurogenic inflammation in the central nervous system. This, in turn, is responsible for anti–analgesic and hyperalgesic effects. There are a number of strategies on how to inhibit this pronociceptive effect and finally improve morphine analgesia.
Informacje o artykuleTytuł
The role of metabolites in morphine analgesic effects
Czasopismo
Numer
Strony
56-59
Opublikowany online
2019-03-01
Wyświetlenia strony
432
Wyświetlenia/pobrania artykułu
728
Rekord bibliograficzny
Varia Medica 2019;3(1):56-59.
Autorzy
Zbigniew Żylicz