Introduction. Sexual dysfunction and impotence are common symptoms of depression, as well as common side effects of antidepressant medication. The aim of this review is to assess the efficacy, safety and clinical applications of trazodone, an oral antidepressant agent in the treatment of erectile dysfunction in the course of depression.
Material and methods. The data sources used were Medline and the other available bibliographies. The trials of poor quality or methodology were not considered.
Conclusions. The literature review releated, that trazodone is efficacious in men with erectile dysfunction (ED), specially of non-organic origin and concomitant depression. It can also be used in state of inhibited libido. The priapism after trazodone treatment turned out more rare than previous trials estimated. Methods of curing this adverse reaction much improved over last years, making using medicines with risk of priapism, more safe.