open access

Vol 23, No 5 (2018)
Published online: 2018-09-01
Submitted: 2018-04-10
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Radiotherapy alone as a method of treatment for sinonasal mucosal melanoma: A report based on six cases and a review of current opinion

Beata Sas-Korczynska, Marian Reinfuss, Jerzy W. Mitus, Elzbieta Pluta, Anna Patla, Tomasz Walasek
DOI: 10.1016/j.rpor.2018.07.014
·
Rep Pract Oncol Radiother 2018;23(5):402-406.

open access

Vol 23, No 5 (2018)
Published online: 2018-09-01
Submitted: 2018-04-10

Abstract

Objectives

Radiotherapy in patients with sinonasal mucosal melanoma (SNMM) was given as alternative treatment to surgery in cases with advanced, inoperable tumors or those not eligible for surgery. We presented the outcomes for patients with SNMM treated with radiotherapy alone.

Material and methods

The retrospective review of 6 consecutive SNMM (nasal cavity – 4 pts. and paranasal sinus – 2 pts.) patients (3 males and 3 females at mean age 64 years) treated between 2008 and 2016 was presented. The stage of disease was: T3 (1 pt.), T4a (3 pts.), T4b (2 pts.); with N0 and M0 in all patients. All patients underwent definitive primary photon radiotherapy (IMRT) alone; dose 66–72 Gy was delivered in 22–24 fractions given in 5 fractions (3 Gy) a week.

Results

The complete remission was observed in all our patients but only one patient survived 5 years without disease. Five patients died due to multiple distant metastases; two of those patients developed associated local recurrence 7–8 months after radiotherapy.

Conclusion

SNMM has a poor prognosis due to its high metastatic potential. Based on our numerically small report and data from literature we concluded that primary radiotherapy alone assured complete remission and even 5-year disease-free survival in only a few individual patients.

Abstract

Objectives

Radiotherapy in patients with sinonasal mucosal melanoma (SNMM) was given as alternative treatment to surgery in cases with advanced, inoperable tumors or those not eligible for surgery. We presented the outcomes for patients with SNMM treated with radiotherapy alone.

Material and methods

The retrospective review of 6 consecutive SNMM (nasal cavity – 4 pts. and paranasal sinus – 2 pts.) patients (3 males and 3 females at mean age 64 years) treated between 2008 and 2016 was presented. The stage of disease was: T3 (1 pt.), T4a (3 pts.), T4b (2 pts.); with N0 and M0 in all patients. All patients underwent definitive primary photon radiotherapy (IMRT) alone; dose 66–72 Gy was delivered in 22–24 fractions given in 5 fractions (3 Gy) a week.

Results

The complete remission was observed in all our patients but only one patient survived 5 years without disease. Five patients died due to multiple distant metastases; two of those patients developed associated local recurrence 7–8 months after radiotherapy.

Conclusion

SNMM has a poor prognosis due to its high metastatic potential. Based on our numerically small report and data from literature we concluded that primary radiotherapy alone assured complete remission and even 5-year disease-free survival in only a few individual patients.

Get Citation

Keywords

Mucosal melanoma; Sinonasal melanoma; Radiotherapy; Charged particle therapy

About this article
Title

Radiotherapy alone as a method of treatment for sinonasal mucosal melanoma: A report based on six cases and a review of current opinion

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 5 (2018)

Pages

402-406

Published online

2018-09-01

DOI

10.1016/j.rpor.2018.07.014

Bibliographic record

Rep Pract Oncol Radiother 2018;23(5):402-406.

Keywords

Mucosal melanoma
Sinonasal melanoma
Radiotherapy
Charged particle therapy

Authors

Beata Sas-Korczynska
Marian Reinfuss
Jerzy W. Mitus
Elzbieta Pluta
Anna Patla
Tomasz Walasek

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