open access

Vol 23, No 5 (2018)
Published online: 2018-09-01
Submitted: 2017-10-20
Get Citation

Bone in the breast? Long term toxicity 21 years after interstitial brachytherapy as a boost

Sara Imboden, Laura Knabben, Michael D. Mueller, Andreas R. Günthert, Kristina Lössl
DOI: 10.1016/j.rpor.2018.06.002
·
Rep Pract Oncol Radiother 2018;23(5):337-340.

open access

Vol 23, No 5 (2018)
Published online: 2018-09-01
Submitted: 2017-10-20

Abstract

An 81-year-old patient developed an exulcerous tumor in her left breast 21 years after breast cancer treatment with lumpectomy and adjuvant radiotherapy. At the time of the initial treatment 21 years ago, whole breast irradiation was performed with a prescribed dose of 48 Gy and a maximal dose of 69 Gy. In addition, the patient received a 14.7 Gy boost with multicatheter brachytherapy as partial breast irradiation.

In general, fat necrosis after radiotherapy, surgery or trauma is a minor problem for patients, but can lead to diagnostic difficulties. The incidence varies: the literature indicates that it occurs in up to 34% of cases. The direct pathogenesis is not clear; it can be due to high radiation dose to the breast, dosimetric inhomogeneities or surgical complications (seromas and inflammation).

The tumor in the case described here, occurring more than two decades after the primary treatment, is a rarity in this extent and is an unusual clinical, radiological, and histological finding. It provides a good example of the need for an individualized approach to treatment.

Abstract

An 81-year-old patient developed an exulcerous tumor in her left breast 21 years after breast cancer treatment with lumpectomy and adjuvant radiotherapy. At the time of the initial treatment 21 years ago, whole breast irradiation was performed with a prescribed dose of 48 Gy and a maximal dose of 69 Gy. In addition, the patient received a 14.7 Gy boost with multicatheter brachytherapy as partial breast irradiation.

In general, fat necrosis after radiotherapy, surgery or trauma is a minor problem for patients, but can lead to diagnostic difficulties. The incidence varies: the literature indicates that it occurs in up to 34% of cases. The direct pathogenesis is not clear; it can be due to high radiation dose to the breast, dosimetric inhomogeneities or surgical complications (seromas and inflammation).

The tumor in the case described here, occurring more than two decades after the primary treatment, is a rarity in this extent and is an unusual clinical, radiological, and histological finding. It provides a good example of the need for an individualized approach to treatment.

Get Citation

Keywords

Breast cancer; Radiotherapy; Partial breast irradiation; Fat necrosis; Breast conservation

About this article
Title

Bone in the breast? Long term toxicity 21 years after interstitial brachytherapy as a boost

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 5 (2018)

Pages

337-340

Published online

2018-09-01

DOI

10.1016/j.rpor.2018.06.002

Bibliographic record

Rep Pract Oncol Radiother 2018;23(5):337-340.

Keywords

Breast cancer
Radiotherapy
Partial breast irradiation
Fat necrosis
Breast conservation

Authors

Sara Imboden
Laura Knabben
Michael D. Mueller
Andreas R. Günthert
Kristina Lössl

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl