open access

Vol 21, No 2 (2016)
Special Issue Papers
Published online: 2016-03-01
Submitted: 2014-04-07
Get Citation

Present status of Accelerator-Based BNCT

Andres Juan Kreiner, Javier Bergueiro, Daniel Cartelli, Matias Baldo, Walter Castell, Javier Gomez Asoia, Javier Padulo, Juan Carlos Suárez Sandín, Marcelo Igarzabal, Julian Erhardt, Daniel Mercuri, Alejandro A. Valda, Daniel M. Minsky, Mario E. Debray, Hector R. Somacal, María Eugenia Capoulat, María S. Herrera, Mariela F. del Grosso, Leonardo Gagetti, Manuel Suarez Anzorena, Nicolas Canepa, Nicolas Real, Marcelo Gun, Hernán Tacca
DOI: 10.1016/j.rpor.2014.11.004
·
Rep Pract Oncol Radiother 2016;21(2):95-101.

open access

Vol 21, No 2 (2016)
Special Issue Papers
Published online: 2016-03-01
Submitted: 2014-04-07

Abstract

Aim

This work aims at giving an updated report of the worldwide status of Accelerator-Based BNCT (AB-BNCT).

Background

There is a generalized perception that the availability of accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of BNCT. Accordingly, in recent years a significant effort has started to develop such machines.

Materials and methods

A variety of possible charged-particle induced nuclear reactions and the characteristics of the resulting neutron spectra are discussed along with the worldwide activity in suitable accelerator development.

Results

Endothermic 7Li(p,n)7Be and 9Be(p,n)9B and exothermic 9Be(d,n)10B are compared. In addition to having much better thermo-mechanical properties than Li, Be as a target leads to stable products. This is a significant advantage for a hospital-based facility. 9Be(p,n)9B needs at least 4–5[[ce:hsp sp="0.25"/]]MeV bombarding energy to have a sufficient yield, while 9Be(d,n)10B can be utilized at about 1.4[[ce:hsp sp="0.25"/]]MeV, implying the smallest possible accelerator. This reaction operating with a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT. The machines considered are electrostatic single ended or tandem accelerators or radiofrequency quadrupoles plus drift tube Linacs.

Conclusions

7Li(p,n)7Be provides one of the best solutions for the production of epithermal neutron beams for deep-seated tumors. However, a Li-based target poses significant technological challenges. Hence, Be has been considered as an alternative target, both in combination with (p,n) and (d,n) reactions. 9Be(d,n)10B at 1.4[[ce:hsp sp="0.25"/]]MeV, with a thin target has been shown to be a realistic option for the treatment of deep-seated lesions.

Abstract

Aim

This work aims at giving an updated report of the worldwide status of Accelerator-Based BNCT (AB-BNCT).

Background

There is a generalized perception that the availability of accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of BNCT. Accordingly, in recent years a significant effort has started to develop such machines.

Materials and methods

A variety of possible charged-particle induced nuclear reactions and the characteristics of the resulting neutron spectra are discussed along with the worldwide activity in suitable accelerator development.

Results

Endothermic 7Li(p,n)7Be and 9Be(p,n)9B and exothermic 9Be(d,n)10B are compared. In addition to having much better thermo-mechanical properties than Li, Be as a target leads to stable products. This is a significant advantage for a hospital-based facility. 9Be(p,n)9B needs at least 4–5[[ce:hsp sp="0.25"/]]MeV bombarding energy to have a sufficient yield, while 9Be(d,n)10B can be utilized at about 1.4[[ce:hsp sp="0.25"/]]MeV, implying the smallest possible accelerator. This reaction operating with a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT. The machines considered are electrostatic single ended or tandem accelerators or radiofrequency quadrupoles plus drift tube Linacs.

Conclusions

7Li(p,n)7Be provides one of the best solutions for the production of epithermal neutron beams for deep-seated tumors. However, a Li-based target poses significant technological challenges. Hence, Be has been considered as an alternative target, both in combination with (p,n) and (d,n) reactions. 9Be(d,n)10B at 1.4[[ce:hsp sp="0.25"/]]MeV, with a thin target has been shown to be a realistic option for the treatment of deep-seated lesions.

Get Citation

Keywords

Accelerator-Based BNCT; Different nuclear reactions and accelerator types; Worldwide activity

About this article
Title

Present status of Accelerator-Based BNCT

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 2 (2016)

Pages

95-101

Published online

2016-03-01

DOI

10.1016/j.rpor.2014.11.004

Bibliographic record

Rep Pract Oncol Radiother 2016;21(2):95-101.

Keywords

Accelerator-Based BNCT
Different nuclear reactions and accelerator types
Worldwide activity

Authors

Andres Juan Kreiner
Javier Bergueiro
Daniel Cartelli
Matias Baldo
Walter Castell
Javier Gomez Asoia
Javier Padulo
Juan Carlos Suárez Sandín
Marcelo Igarzabal
Julian Erhardt
Daniel Mercuri
Alejandro A. Valda
Daniel M. Minsky
Mario E. Debray
Hector R. Somacal
María Eugenia Capoulat
María S. Herrera
Mariela F. del Grosso
Leonardo Gagetti
Manuel Suarez Anzorena
Nicolas Canepa
Nicolas Real
Marcelo Gun
Hernán Tacca

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl