open access

Vol 19, No 3 (2014)
Published online: 2014-05-01
Submitted: 2013-04-30
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The impact of PET/CT scanning on the size of target volumes, radiation exposure of organs at risk, TCP and NTCP, in the radiotherapy planning of non-small cell lung cancer

Radovan Vojtíšek, Jan Mužík, Pavel Šlampa, Marie Budíková, Jaroslav Hejsek, Petr Smolák, Jiří Ferda, Jindřich Fínek
DOI: 10.1016/j.rpor.2013.09.006
·
Rep Pract Oncol Radiother 2014;19(3):182-190.

open access

Vol 19, No 3 (2014)
Published online: 2014-05-01
Submitted: 2013-04-30

Abstract

Aim

To compare radiotherapy plans made according to CT and PET/CT and to investigate the impact of changes in target volumes on tumour control probability (TCP), normal tissue complication probability (NTCP) and the impact of PET/CT on the staging and treatment strategy.

Background

Contemporary studies have proven that PET/CT attains higher sensitivity and specificity in the diagnosis of lung cancer and also leads to higher accuracy than CT alone in the process of target volume delineation in NSCLC.

Materials and methods

Between October 2009 and March 2012, 31 patients with locally advanced NSCLC, who had been referred to radical radiotherapy were involved in our study. They all underwent planning PET/CT examination. Then we carried out two separate delineations of target volumes and two radiotherapy plans and we compared the following parameters of those plans: staging, treatment purpose, the size of GTV and PTV and the exposure of organs at risk (OAR). TCP and NTCP were also compared.

Results

PET/CT information led to a significant decrease in the sizes of target volumes, which had the impact on the radiation exposure of OARs. The reduction of target volume sizes was not reflected in the significant increase of the TCP value. We found that there is a very strong direct linear relationship between all evaluated dosimetric parameters and NTCP values of all evaluated OARs.

Conclusions

Our study found that the use of planning PET/CT in the radiotherapy planning of NSCLC has a crucial impact on the precise determination of target volumes, more precise staging of the disease and thus also on possible changes of treatment strategy.

Abstract

Aim

To compare radiotherapy plans made according to CT and PET/CT and to investigate the impact of changes in target volumes on tumour control probability (TCP), normal tissue complication probability (NTCP) and the impact of PET/CT on the staging and treatment strategy.

Background

Contemporary studies have proven that PET/CT attains higher sensitivity and specificity in the diagnosis of lung cancer and also leads to higher accuracy than CT alone in the process of target volume delineation in NSCLC.

Materials and methods

Between October 2009 and March 2012, 31 patients with locally advanced NSCLC, who had been referred to radical radiotherapy were involved in our study. They all underwent planning PET/CT examination. Then we carried out two separate delineations of target volumes and two radiotherapy plans and we compared the following parameters of those plans: staging, treatment purpose, the size of GTV and PTV and the exposure of organs at risk (OAR). TCP and NTCP were also compared.

Results

PET/CT information led to a significant decrease in the sizes of target volumes, which had the impact on the radiation exposure of OARs. The reduction of target volume sizes was not reflected in the significant increase of the TCP value. We found that there is a very strong direct linear relationship between all evaluated dosimetric parameters and NTCP values of all evaluated OARs.

Conclusions

Our study found that the use of planning PET/CT in the radiotherapy planning of NSCLC has a crucial impact on the precise determination of target volumes, more precise staging of the disease and thus also on possible changes of treatment strategy.

Get Citation

Keywords

Non-small cell lung cancer; PET/CT; Radiotherapy planning; TCP; NTCP

About this article
Title

The impact of PET/CT scanning on the size of target volumes, radiation exposure of organs at risk, TCP and NTCP, in the radiotherapy planning of non-small cell lung cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 3 (2014)

Pages

182-190

Published online

2014-05-01

DOI

10.1016/j.rpor.2013.09.006

Bibliographic record

Rep Pract Oncol Radiother 2014;19(3):182-190.

Keywords

Non-small cell lung cancer
PET/CT
Radiotherapy planning
TCP
NTCP

Authors

Radovan Vojtíšek
Jan Mužík
Pavel Šlampa
Marie Budíková
Jaroslav Hejsek
Petr Smolák
Jiří Ferda
Jindřich Fínek

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