open access

Vol 19, No 3 (2014)
Published online: 2014-05-01
Submitted: 2013-01-19
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Clinicopathological features and prognosis of triple negative breast cancer in Kuwait: A comparative/perspective analysis

Mohammed S. Fayaz, Mustafa S. El-Sherify, Amany El-Basmy, Sadeq A. Zlouf, Nashwa Nazmy, Thomas George, Susan Samir, Gerges Attia, Heba Eissa
DOI: 10.1016/j.rpor.2013.08.007
·
Rep Pract Oncol Radiother 2014;19(3):173-181.

open access

Vol 19, No 3 (2014)
Published online: 2014-05-01
Submitted: 2013-01-19

Abstract

Aim

The aim of this study was to determine the incidence of TNBC in Kuwait, to analyze the clinicopathologic features and prognosis of this type of breast cancer, and compare it with reports from other regions of the world.

Background

Triple negative breast cancer (TNBC) is defined as a subtype that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2). There is a growing evidence of the heterogeneity of such entity on the molecular level that may cause discrete outcomes.

Methods

We analyzed the clinicopathologic features of 363 TNBC cases which were diagnosed in Kuwait from July 1999 to June 2009. The disease-free survival (DFS) and overall survival (OS) were analyzed by Kaplan–Meier method. Comparison was done with reports from USA, Europe, Middle and Far East.

Results

Among 2986 patients diagnosed with breast cancer in Kuwait, 363 patients (12.2%) were TNBC. The median age was 48 years, 57.2% had lymph nodes (LN) metastasis, 56.9% were of grade III tumor and 41.9% had stage II disease. 81% developed recurrences and 75% of deaths occurred by 2.5 years after treatment. There is marked variation of clinicopathologic features according to country of patients’ cohort.

Conclusion

The incidence of TNBC in our study is similar to other studies. TNBC patients showed an early major recurrence surge peaking at approximately year 2.5. Regional variation of clinicopathologic features indicates a need for molecular studies to define underlying molecular features and its impact on survival.

Abstract

Aim

The aim of this study was to determine the incidence of TNBC in Kuwait, to analyze the clinicopathologic features and prognosis of this type of breast cancer, and compare it with reports from other regions of the world.

Background

Triple negative breast cancer (TNBC) is defined as a subtype that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2). There is a growing evidence of the heterogeneity of such entity on the molecular level that may cause discrete outcomes.

Methods

We analyzed the clinicopathologic features of 363 TNBC cases which were diagnosed in Kuwait from July 1999 to June 2009. The disease-free survival (DFS) and overall survival (OS) were analyzed by Kaplan–Meier method. Comparison was done with reports from USA, Europe, Middle and Far East.

Results

Among 2986 patients diagnosed with breast cancer in Kuwait, 363 patients (12.2%) were TNBC. The median age was 48 years, 57.2% had lymph nodes (LN) metastasis, 56.9% were of grade III tumor and 41.9% had stage II disease. 81% developed recurrences and 75% of deaths occurred by 2.5 years after treatment. There is marked variation of clinicopathologic features according to country of patients’ cohort.

Conclusion

The incidence of TNBC in our study is similar to other studies. TNBC patients showed an early major recurrence surge peaking at approximately year 2.5. Regional variation of clinicopathologic features indicates a need for molecular studies to define underlying molecular features and its impact on survival.

Get Citation

Keywords

Triple negative; Breast cancer; Clinicopathological; Epidemiology; Variation

About this article
Title

Clinicopathological features and prognosis of triple negative breast cancer in Kuwait: A comparative/perspective analysis

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 3 (2014)

Pages

173-181

Published online

2014-05-01

DOI

10.1016/j.rpor.2013.08.007

Bibliographic record

Rep Pract Oncol Radiother 2014;19(3):173-181.

Keywords

Triple negative
Breast cancer
Clinicopathological
Epidemiology
Variation

Authors

Mohammed S. Fayaz
Mustafa S. El-Sherify
Amany El-Basmy
Sadeq A. Zlouf
Nashwa Nazmy
Thomas George
Susan Samir
Gerges Attia
Heba Eissa

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