open access

Vol 16, No 5 (2011)
Published online: 2011-09-01
Submitted: 2010-12-22
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Prognostic role of c-met expression in breast cancer patients

Iwona Gisterek, Ewelina Lata, Agnieszka Halon, Rafal Matkowski, Jolanta Szelachowska, Przemyslaw Biecek, Jan Kornafel
DOI: 10.1016/j.rpor.2011.04.001
·
Rep Pract Oncol Radiother 2011;16(5):173-177.

open access

Vol 16, No 5 (2011)
Published online: 2011-09-01
Submitted: 2010-12-22

Abstract

Background

Hepatocyte growth factor plays an important role in tumor growth, metastasis and angiogenesis. C-met is HGF's high affinity receptor.

Aim

The aim of the study was to assess the correlations between c-met expression and clinic-pathological factors in breast cancer tissues. Furthermore, the purpose of the study was to evaluate the prognostic value of the hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients.

Materials and methods

Tumor samples were collected from 302 patients with breast carcinoma treated with primary surgery. We have assessed the percentage of tumor cells with c-met expression, the intensity of reaction and the ratio of these two factors—immunoreactivity according to the Remmele score.

Results

We have observed no correlations between HGFR immunoreactivities and clinical parameters (tumor size, grade, axillary lymph node status, age). In 5-year observation we have found prognostic value of assessing c-met immunoreactivity in primary tumor.

Conclusion

Our study has revealed prognostic value of c-met. Unlike in other authors’ studies, our patients’ group is very homogenous which might contribute to obtained results.

Abstract

Background

Hepatocyte growth factor plays an important role in tumor growth, metastasis and angiogenesis. C-met is HGF's high affinity receptor.

Aim

The aim of the study was to assess the correlations between c-met expression and clinic-pathological factors in breast cancer tissues. Furthermore, the purpose of the study was to evaluate the prognostic value of the hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients.

Materials and methods

Tumor samples were collected from 302 patients with breast carcinoma treated with primary surgery. We have assessed the percentage of tumor cells with c-met expression, the intensity of reaction and the ratio of these two factors—immunoreactivity according to the Remmele score.

Results

We have observed no correlations between HGFR immunoreactivities and clinical parameters (tumor size, grade, axillary lymph node status, age). In 5-year observation we have found prognostic value of assessing c-met immunoreactivity in primary tumor.

Conclusion

Our study has revealed prognostic value of c-met. Unlike in other authors’ studies, our patients’ group is very homogenous which might contribute to obtained results.

Get Citation

Keywords

c-met; Breast cancer; Prognostic factor

About this article
Title

Prognostic role of c-met expression in breast cancer patients

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 16, No 5 (2011)

Pages

173-177

Published online

2011-09-01

DOI

10.1016/j.rpor.2011.04.001

Bibliographic record

Rep Pract Oncol Radiother 2011;16(5):173-177.

Keywords

c-met
Breast cancer
Prognostic factor

Authors

Iwona Gisterek
Ewelina Lata
Agnieszka Halon
Rafal Matkowski
Jolanta Szelachowska
Przemyslaw Biecek
Jan Kornafel

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