open access

Vol 16, No 3 (2011)
Published online: 2011-05-01
Submitted: 2010-12-29
Get Citation

Application of IMRT in adjuvant treatment of soft tissue sarcomas of the thigh—Preliminary results

Anna Śladowska, Marcin Hetnał, Paweł Dymek, Damian Kabat, Kamil Kisielewicz, Michał Wawrzak, Paweł Zawadzki, Jan Lesiak, Edward Byrski, Michał Waligórski
DOI: 10.1016/j.rpor.2011.02.006
·
Rep Pract Oncol Radiother 2011;16(3):110-114.

open access

Vol 16, No 3 (2011)
Published online: 2011-05-01
Submitted: 2010-12-29

Abstract

Background

Fracture of the femur is the most frequent late complication in patients with soft tissue sarcomas (STS) who receive external beam radiotherapy after limb-sparing surgery.

Aim

To reduce the risk of bone fracture following radiotherapy of STS of the thigh, we minimized the dose to the femur and to surrounding normal tissues by applying intensity modulated radiation therapy (IMRT). We report preliminary results of post-surgery IMRT of the thigh in patients with STS in this extremity.

Materials and methods

10 adult patients undergoing post-operative radiotherapy of STS of the thigh were treated using IMRT. Clinical IMRT plans with simultaneous integrated boost (SIB) and 3-phase three-dimensional conformal radiotherapy (3D-CRT) were designed to adequately treat the planning target volume and to spare the femur to the largest extent possible. Dose distributions and dose-volume histograms were compared.

Results

For either technique, a comparable target coverage was achieved; however, target volume was better covered and critical structures were better spared in IMRT plans. Mean and maximum doses to OAR structures were also significantly reduced in the IMRT plans. On average, the mean dose to the femur in 3D-CRT plans was about two times higher than that in IMRT plans.

Conclusion

Compared with 3D-CRT, the application of IMRT improves the dose distribution within the concave target volumes and reduces dose to the OAR structures without compromising target coverage.

Abstract

Background

Fracture of the femur is the most frequent late complication in patients with soft tissue sarcomas (STS) who receive external beam radiotherapy after limb-sparing surgery.

Aim

To reduce the risk of bone fracture following radiotherapy of STS of the thigh, we minimized the dose to the femur and to surrounding normal tissues by applying intensity modulated radiation therapy (IMRT). We report preliminary results of post-surgery IMRT of the thigh in patients with STS in this extremity.

Materials and methods

10 adult patients undergoing post-operative radiotherapy of STS of the thigh were treated using IMRT. Clinical IMRT plans with simultaneous integrated boost (SIB) and 3-phase three-dimensional conformal radiotherapy (3D-CRT) were designed to adequately treat the planning target volume and to spare the femur to the largest extent possible. Dose distributions and dose-volume histograms were compared.

Results

For either technique, a comparable target coverage was achieved; however, target volume was better covered and critical structures were better spared in IMRT plans. Mean and maximum doses to OAR structures were also significantly reduced in the IMRT plans. On average, the mean dose to the femur in 3D-CRT plans was about two times higher than that in IMRT plans.

Conclusion

Compared with 3D-CRT, the application of IMRT improves the dose distribution within the concave target volumes and reduces dose to the OAR structures without compromising target coverage.

Get Citation

Keywords

IMRT; 3D-CRT; Soft tissue sarcoma

About this article
Title

Application of IMRT in adjuvant treatment of soft tissue sarcomas of the thigh—Preliminary results

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 16, No 3 (2011)

Pages

110-114

Published online

2011-05-01

DOI

10.1016/j.rpor.2011.02.006

Bibliographic record

Rep Pract Oncol Radiother 2011;16(3):110-114.

Keywords

IMRT
3D-CRT
Soft tissue sarcoma

Authors

Anna Śladowska
Marcin Hetnał
Paweł Dymek
Damian Kabat
Kamil Kisielewicz
Michał Wawrzak
Paweł Zawadzki
Jan Lesiak
Edward Byrski
Michał Waligórski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl