open access

Vol 15, No 6 (2010)
Published online: 2010-11-01
Submitted: 2010-05-11
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Normoxic polymer gel dosimetry using less toxic monomer of N-isopropyl acrylamide and X-ray computed tomography for radiation therapy applications

Seyed-Mostafa Ghavami, Asghar Mesbahi, Ismaeel Pesianian, Abbas Shafaee, Mohammad-Reza Aliparasti
DOI: 10.1016/j.rpor.2010.10.001
·
Rep Pract Oncol Radiother 2010;15(6):172-175.

open access

Vol 15, No 6 (2010)
Published online: 2010-11-01
Submitted: 2010-05-11

Abstract

Background

Polymer gel dosimetry has been used extensively in radiation therapy for its capability in depicting a three dimensional view of absorbed dose distribution. However, more studies are required to find less toxic and more efficient polymers for application in radiotherapy dosimetry.

Aim

The purpose of this work was to evaluate the N-isopropyl acrylamide (NIPAM) gel dosimetric characteristics and optimize the protocol for X-ray computed tomography (CT) imaging of gel dosimeters for radiation therapy application.

Material and methods

A polymer gel dosimeter based on NIPAM monomer was prepared and irradiated with 60Co photons. The CT number changes following irradiation were extracted from CT images obtained with different sets of imaging parameters.

Results

The results showed the dose sensitivity of ΔNCT (H)[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.282[[ce:hsp sp="0.25"/]]±[[ce:hsp sp="0.25"/]]0.018 (H[[ce:hsp sp="0.25"/]]Gy−1) for NIPAM gel dosimeter. The optimized set of imaging exposure parameters was 120[[ce:hsp sp="0.25"/]]kVp and 200[[ce:hsp sp="0.25"/]]mA with the 10[[ce:hsp sp="0.25"/]]mm slice thickness. Results of the depth dose measurement with gel dosimeter showed a great discrepancy with the actual depth dose data.

Conclusion

According to the current study, NIPAM-based gel dosimetry with X-ray CT imaging needs more technical development and formulation refinement to be used for radiation therapy application.

Abstract

Background

Polymer gel dosimetry has been used extensively in radiation therapy for its capability in depicting a three dimensional view of absorbed dose distribution. However, more studies are required to find less toxic and more efficient polymers for application in radiotherapy dosimetry.

Aim

The purpose of this work was to evaluate the N-isopropyl acrylamide (NIPAM) gel dosimetric characteristics and optimize the protocol for X-ray computed tomography (CT) imaging of gel dosimeters for radiation therapy application.

Material and methods

A polymer gel dosimeter based on NIPAM monomer was prepared and irradiated with 60Co photons. The CT number changes following irradiation were extracted from CT images obtained with different sets of imaging parameters.

Results

The results showed the dose sensitivity of ΔNCT (H)[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.282[[ce:hsp sp="0.25"/]]±[[ce:hsp sp="0.25"/]]0.018 (H[[ce:hsp sp="0.25"/]]Gy−1) for NIPAM gel dosimeter. The optimized set of imaging exposure parameters was 120[[ce:hsp sp="0.25"/]]kVp and 200[[ce:hsp sp="0.25"/]]mA with the 10[[ce:hsp sp="0.25"/]]mm slice thickness. Results of the depth dose measurement with gel dosimeter showed a great discrepancy with the actual depth dose data.

Conclusion

According to the current study, NIPAM-based gel dosimetry with X-ray CT imaging needs more technical development and formulation refinement to be used for radiation therapy application.

Get Citation

Keywords

Polymer gel dosimetry; X-ray computed tomography; Radiation therapy

About this article
Title

Normoxic polymer gel dosimetry using less toxic monomer of N-isopropyl acrylamide and X-ray computed tomography for radiation therapy applications

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 15, No 6 (2010)

Pages

172-175

Published online

2010-11-01

DOI

10.1016/j.rpor.2010.10.001

Bibliographic record

Rep Pract Oncol Radiother 2010;15(6):172-175.

Keywords

Polymer gel dosimetry
X-ray computed tomography
Radiation therapy

Authors

Seyed-Mostafa Ghavami
Asghar Mesbahi
Ismaeel Pesianian
Abbas Shafaee
Mohammad-Reza Aliparasti

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