open access

Vol 15, No 6 (2010)
Published online: 2010-11-01
Submitted: 2010-04-22
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The histopathologic evaluation of soft tissue changes in rabbit extremity after different dose-fractionation schemes of interstitial high dose rate (HDR) brachytherapy

Ozge Petek Erpolat, Muge Akmansu, Mehmet Dogan, Huseyin Bora, Ceren Kurugol, Omer Uluoglu
DOI: 10.1016/j.rpor.2010.09.002
·
Rep Pract Oncol Radiother 2010;15(6):165-171.

open access

Vol 15, No 6 (2010)
Published online: 2010-11-01
Submitted: 2010-04-22

Abstract

Background

The use of HDR in the treatment of soft tissue sarcoma had been on the rise. However, there was limited study to evaluate the effect of different fractionation schemes on soft tissue and the optimal HDR scheme.

Aims

We aimed to assess the histopathologic changes on soft tissue after different HDR brachytherapy doses.

Methods

The subjects were divided into three groups. Each group included 10 limbs. Group A had only an applicator without radiation, group B received a total of 24[[ce:hsp sp="0.25"/]]Gy at 6[[ce:hsp sp="0.25"/]]Gy per fraction, twice a day, and group C received a total of 13.5[[ce:hsp sp="0.25"/]]Gy in a single fraction. The histopathologic findings were grouped into soft tissue pathology-1 (edema, inflammation, endothelial proliferation, necrosis) and soft tissue pathology-2 (atrophy, calcification, vascular hyalinization, fibrosis) (STP-1–2).

Results

The highest mean grade values of STP-1 and STP-2 were observed in group C (0.95 and 1.45) in comparison to group A (0.45 and 0.85) and group B (0.65 and 0.9). The difference in STP-1 was found significant only between groups A and C and the difference in STP-2 was found both between groups A and C and groups B and C.

Conclusion

In our experimental study it was shown that the fractionated interstitial HDR had both lower rate and severity of toxicity in comparison to a single high dose fraction. Before using a single fractionated regimen in the clinic, the increased morbidity related to the irreversible early toxicities or progressive late toxicities should be kept in mind.

Abstract

Background

The use of HDR in the treatment of soft tissue sarcoma had been on the rise. However, there was limited study to evaluate the effect of different fractionation schemes on soft tissue and the optimal HDR scheme.

Aims

We aimed to assess the histopathologic changes on soft tissue after different HDR brachytherapy doses.

Methods

The subjects were divided into three groups. Each group included 10 limbs. Group A had only an applicator without radiation, group B received a total of 24[[ce:hsp sp="0.25"/]]Gy at 6[[ce:hsp sp="0.25"/]]Gy per fraction, twice a day, and group C received a total of 13.5[[ce:hsp sp="0.25"/]]Gy in a single fraction. The histopathologic findings were grouped into soft tissue pathology-1 (edema, inflammation, endothelial proliferation, necrosis) and soft tissue pathology-2 (atrophy, calcification, vascular hyalinization, fibrosis) (STP-1–2).

Results

The highest mean grade values of STP-1 and STP-2 were observed in group C (0.95 and 1.45) in comparison to group A (0.45 and 0.85) and group B (0.65 and 0.9). The difference in STP-1 was found significant only between groups A and C and the difference in STP-2 was found both between groups A and C and groups B and C.

Conclusion

In our experimental study it was shown that the fractionated interstitial HDR had both lower rate and severity of toxicity in comparison to a single high dose fraction. Before using a single fractionated regimen in the clinic, the increased morbidity related to the irreversible early toxicities or progressive late toxicities should be kept in mind.

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Keywords

Interstitial HDR brachytherapy; Dose and fractionation; Soft tissue

About this article
Title

The histopathologic evaluation of soft tissue changes in rabbit extremity after different dose-fractionation schemes of interstitial high dose rate (HDR) brachytherapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 15, No 6 (2010)

Pages

165-171

Published online

2010-11-01

DOI

10.1016/j.rpor.2010.09.002

Bibliographic record

Rep Pract Oncol Radiother 2010;15(6):165-171.

Keywords

Interstitial HDR brachytherapy
Dose and fractionation
Soft tissue

Authors

Ozge Petek Erpolat
Muge Akmansu
Mehmet Dogan
Huseyin Bora
Ceren Kurugol
Omer Uluoglu

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