open access

Vol 13, No 2 (2008)
Untitled
Published online: 2008-03-01
Submitted: 2007-11-08
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Assessment of tumor control probability for high-dose-rate interstitial brachytherapy implants

Than S. KEHWAR, Syed F. AKBER
DOI: 10.1016/S1507-1367(10)60085-5
·
Rep Pract Oncol Radiother 2008;13(2):74-77.

open access

Vol 13, No 2 (2008)
Untitled
Published online: 2008-03-01
Submitted: 2007-11-08

Abstract

Aim

The study was designed to propose a novel concept of biologically effective equivalent uniform dose to calculate tumor control probability for HDR implants.

Materials and Methods

The expression of biologically effective equivalent uniform dose was derived for non-uniform dose distribution in HDR implants using quality indices and voxel-based tumor control probability.

Results

The results of this study show that high dose regions of the implant have higher tumor control probability. But these regions may also have a large number of normal cells and consequently may lead to severe normal tissue complications. If tumor coverage was not proper then the overall tumor control probability would be low and might result in tumor recurrence. Higher values of external volume index, dose non-uniformity ratio and overdose volume index were related to higher normal tissue complication rates outside and inside the implants.

Conclusion

The present concept may provide an alternative approach to calculate tumor control probability for HDR implants.

Abstract

Aim

The study was designed to propose a novel concept of biologically effective equivalent uniform dose to calculate tumor control probability for HDR implants.

Materials and Methods

The expression of biologically effective equivalent uniform dose was derived for non-uniform dose distribution in HDR implants using quality indices and voxel-based tumor control probability.

Results

The results of this study show that high dose regions of the implant have higher tumor control probability. But these regions may also have a large number of normal cells and consequently may lead to severe normal tissue complications. If tumor coverage was not proper then the overall tumor control probability would be low and might result in tumor recurrence. Higher values of external volume index, dose non-uniformity ratio and overdose volume index were related to higher normal tissue complication rates outside and inside the implants.

Conclusion

The present concept may provide an alternative approach to calculate tumor control probability for HDR implants.

Get Citation

Keywords

HDR interstitial implants; quality indices; non-optimization; geometric optimization of volume; biologically effective equivalent uniform dose

About this article
Title

Assessment of tumor control probability for high-dose-rate interstitial brachytherapy implants

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 13, No 2 (2008)

Pages

74-77

Published online

2008-03-01

DOI

10.1016/S1507-1367(10)60085-5

Bibliographic record

Rep Pract Oncol Radiother 2008;13(2):74-77.

Keywords

HDR interstitial implants
quality indices
non-optimization
geometric optimization of volume
biologically effective equivalent uniform dose

Authors

Than S. KEHWAR
Syed F. AKBER

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