open access
Dissemination of malignant gliomas beyond the central nervous system
open access
Abstract
Background
Gliomas are the most frequently diagnosed primary intracranial tumours in adults. This group incorporates astrocytomas, oligodendrogliomas and ependymomas. Glioma treatment in adults usually means surgery and radiotherapy, and in the case of poorly differentiated tumours, chemotherapy may also be applied. Failures in the treatment of malignant gliomas are mostly local recurrences, intracranial dissemination and, very seldom, metastases beyond the central nervous system.
Aim
The aim of this paper was to present two instances of extraneural dissemination in cases of malignant glioma of the brain.
Materials/Methods
Two patients with dissemination of malignant glioma were diagnosed and treated in our department during the last 20 years.
Results
Treatment effects were poor.
Conclusions
Extraneural brain tumour dissemination is infrequent and their treatment remains an unsolved problem. Treatment is similar to that of primary glioma, especially in cases with high dynamics.
Neither chemotherapy nor radiotherapy are able to produce even a short term palliative effect.
Abstract
Background
Gliomas are the most frequently diagnosed primary intracranial tumours in adults. This group incorporates astrocytomas, oligodendrogliomas and ependymomas. Glioma treatment in adults usually means surgery and radiotherapy, and in the case of poorly differentiated tumours, chemotherapy may also be applied. Failures in the treatment of malignant gliomas are mostly local recurrences, intracranial dissemination and, very seldom, metastases beyond the central nervous system.
Aim
The aim of this paper was to present two instances of extraneural dissemination in cases of malignant glioma of the brain.
Materials/Methods
Two patients with dissemination of malignant glioma were diagnosed and treated in our department during the last 20 years.
Results
Treatment effects were poor.
Conclusions
Extraneural brain tumour dissemination is infrequent and their treatment remains an unsolved problem. Treatment is similar to that of primary glioma, especially in cases with high dynamics.
Neither chemotherapy nor radiotherapy are able to produce even a short term palliative effect.
Keywords
brain tumour; malignant glioma; dissemination of malignant gliomas
About this articleTitle
Dissemination of malignant gliomas beyond the central nervous system
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
101-104
Published online
2006-01-01
DOI
10.1016/S1507-1367(06)71055-0
Bibliographic record
Rep Pract Oncol Radiother 2006;11(2):101-104.
Keywords
brain tumour
malignant glioma
dissemination of malignant gliomas
Authors
Maria L. Pamucka
Lidia Czopkiewicz
Ewa Skrzypczyńska
Piotr Tokar