Sentinel lymph node in colorectal cancer
Abstract
Introduction
In the paper a review of the literature on the usefulness of the sentinel lymph node (SLN) identification in clinical staging of the colorectal cancer was performed. Studies conducted In different surgical departments were analyzed. Crucial elements in prognosis in patients with colorectal cancer and mistakes made in clinical staging of theses patients were pointed out. Lymph nodes metastases warrants the adjuvant therapy and improves results of treatment. The diagnostic methods used at the moment are not very accurate in clinical staging, therefore a search for the new methods, which would enable more precise staging and at the same time the suitable treatment is being made.
Material and methods
The sentinel node concept and the benefits of its identification are discussed. Techniques of the SLN dying (dyes, application) are presented.
Results
The diagnostic efficacy of the method in different studies and the detailed pathological examination (haematoxylin-eosin, immunohistochemistry, molecular techniques) is being analyzed. Positive and false negative results in the studies are evaluated.
Conclusion
The usefulness of the method and application in the clinical setting in colorectal cancer is shown, still further studies are needed.
Keywords: colorectal cancersentinel lymph nodeadvanced cancer stage