open access

Vol 9, No 6 (2004)
Published online: 2004-01-01
Submitted: 2004-04-06
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The presence of Candida albicans in the oral cavity and the total num-ber of lymphocytes in patients with head and neck neoplasms

Artur Stryjski, Maria Borysewicz-Lewicka
DOI: 10.1016/S1507-1367(04)71035-4
·
Rep Pract Oncol Radiother 2004;9(6):249-252.

open access

Vol 9, No 6 (2004)
Published online: 2004-01-01
Submitted: 2004-04-06

Abstract

Objectives

Radiation therapy induces and/or exacerbates mycotic infection. The purpose of the present work was to determine the exis-tence of mycological changes in the oral cavity in patients (pts) treated by radiotherapy because of head and neck neoplasms, and to determine the existence of dependence between the number of lymphocytes and neutrocytes and the increase in the number of Candida albicans.

Materials and method

The material from the oral cavity was taken from 50 pts with head and neck neoplasms treated at the Wielkopolskie Centrum Onkologii (Great Poland Cancer Centre) in Poznań. Patients received radiotherapy in a dose of 6 000 – 7 000 cGy over a period of 6 – 7 weeks. The control group consisted of 20 pts treated at the same hospital for cancer other than head and neck cancer. The patients did not receive radiotherapy treatment. In all pts mycological culture was carried out and the condition of immunity was examined on the basis of the total number of lymphocytes (CLL) and the level of neutrocytes.

Results

The data showed that after treatment the number of pts with positive results of the mycologically cultured examinations on Candida ID increased. At the same time a decrease in CLL was observed. After radiotherapy CLL per 1 mm3 was less than 1000, and the number of Candida more then 5, compared with 4% of pts before radiotherapy. The level of neutrocytes in non of the pts decreased to less than 2 000 per 1 mm3.

Conclusion

Our study suggess that radiotherapy may have an effect on the development of mycological infection, among other things, through the decreace in immunity.

Abstract

Objectives

Radiation therapy induces and/or exacerbates mycotic infection. The purpose of the present work was to determine the exis-tence of mycological changes in the oral cavity in patients (pts) treated by radiotherapy because of head and neck neoplasms, and to determine the existence of dependence between the number of lymphocytes and neutrocytes and the increase in the number of Candida albicans.

Materials and method

The material from the oral cavity was taken from 50 pts with head and neck neoplasms treated at the Wielkopolskie Centrum Onkologii (Great Poland Cancer Centre) in Poznań. Patients received radiotherapy in a dose of 6 000 – 7 000 cGy over a period of 6 – 7 weeks. The control group consisted of 20 pts treated at the same hospital for cancer other than head and neck cancer. The patients did not receive radiotherapy treatment. In all pts mycological culture was carried out and the condition of immunity was examined on the basis of the total number of lymphocytes (CLL) and the level of neutrocytes.

Results

The data showed that after treatment the number of pts with positive results of the mycologically cultured examinations on Candida ID increased. At the same time a decrease in CLL was observed. After radiotherapy CLL per 1 mm3 was less than 1000, and the number of Candida more then 5, compared with 4% of pts before radiotherapy. The level of neutrocytes in non of the pts decreased to less than 2 000 per 1 mm3.

Conclusion

Our study suggess that radiotherapy may have an effect on the development of mycological infection, among other things, through the decreace in immunity.

Get Citation

Keywords

radiotherapy; Candida albicans; lymphocyte; immunity

About this article
Title

The presence of Candida albicans in the oral cavity and the total num-ber of lymphocytes in patients with head and neck neoplasms

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 9, No 6 (2004)

Pages

249-252

Published online

2004-01-01

DOI

10.1016/S1507-1367(04)71035-4

Bibliographic record

Rep Pract Oncol Radiother 2004;9(6):249-252.

Keywords

radiotherapy
Candida albicans
lymphocyte
immunity

Authors

Artur Stryjski
Maria Borysewicz-Lewicka

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