open access

Vol 9, No 4 (2004)
Published online: 2004-01-01
Submitted: 2004-01-31
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Radiation myelopathy: a radiobiological review

Alireza Shirazi, Seied Rabie Mahdavi, Klaus Rudiger Trott
DOI: 10.1016/S1507-1367(04)71019-6
·
Rep Pract Oncol Radiother 2004;9(4):119-127.

open access

Vol 9, No 4 (2004)
Published online: 2004-01-01
Submitted: 2004-01-31

Abstract

Purpose

In radiotherapy the risk of radiation myelopathy is radiobiologically considerable. This review aims to outline future radiobiological research to get closer to the mechanism of radiation myelopathy.

Methods

Different regimes and techniques of irradiation that deliver doses to the spinal cord lead to the development of radiation myelopathy. Up to now, interpretations of injuries have been based entirely on morphological observations and histological analysis.

Results

Using paralysis as the endpoint, large fraction size data were consistent with the linear quadratic model (α/β=2.41 Gy). Small fraction size data gave a much smaller value of α/β (0.48 Gy).

Conclusion

A possible explanation is the interaction of two different groups of target cells with different fractionation sensitivities and, therefore, different α/β values. This duality suggests that spinal cord vascular endothelial changes, both in the morphology and secretory profile, may convey information in addition to the definition of various cells that participate in the evolution of radiation myelopathy.

Abstract

Purpose

In radiotherapy the risk of radiation myelopathy is radiobiologically considerable. This review aims to outline future radiobiological research to get closer to the mechanism of radiation myelopathy.

Methods

Different regimes and techniques of irradiation that deliver doses to the spinal cord lead to the development of radiation myelopathy. Up to now, interpretations of injuries have been based entirely on morphological observations and histological analysis.

Results

Using paralysis as the endpoint, large fraction size data were consistent with the linear quadratic model (α/β=2.41 Gy). Small fraction size data gave a much smaller value of α/β (0.48 Gy).

Conclusion

A possible explanation is the interaction of two different groups of target cells with different fractionation sensitivities and, therefore, different α/β values. This duality suggests that spinal cord vascular endothelial changes, both in the morphology and secretory profile, may convey information in addition to the definition of various cells that participate in the evolution of radiation myelopathy.

Get Citation

Keywords

radiobiology; radiation myelopathy; radiosensitivity; immunohistopathology; prostaglandin

About this article
Title

Radiation myelopathy: a radiobiological review

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 9, No 4 (2004)

Pages

119-127

Published online

2004-01-01

DOI

10.1016/S1507-1367(04)71019-6

Bibliographic record

Rep Pract Oncol Radiother 2004;9(4):119-127.

Keywords

radiobiology
radiation myelopathy
radiosensitivity
immunohistopathology
prostaglandin

Authors

Alireza Shirazi
Seied Rabie Mahdavi
Klaus Rudiger Trott

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