open access

Vol 7, No 1 (2002)
Published online: 2002-01-01
Submitted: 2001-05-10
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The effect of altered fractionation schedule on the spinal cord response: radiobiological considerations

Sanjay S. Supe, K.M. Ganesh, J. Velmurugan, B.S. Rana, B.N. Sankar
DOI: 10.1016/S1507-1367(02)70977-2
·
Rep Pract Oncol Radiother 2002;7(1):27-35.

open access

Vol 7, No 1 (2002)
Published online: 2002-01-01
Submitted: 2001-05-10

Abstract

Increased fractionation spares late reacting normal tissues more than acute reacting normal tissues. A linear quadratic model is valid from large dose per fraction down to dose per fraction of 2 Gy. Experimental studies on animals and clinical studies on the spinal cord tolerance have shown incidences of myelopathy at doses lower than 50 Gy. The α/β value of the linear quadratic model have been lower for low doses per fraction, indicating a sparing effect of altered fractionation for spinal cord myelitis. Animal data, clinical and radiobiological explanations suggest limitation of the radiobiological models. Further data suggest that one must not assume the spinal cord to have a greater tolerance at doses per fraction below the conventional dose per fraction of 2 Gy.

Abstract

Increased fractionation spares late reacting normal tissues more than acute reacting normal tissues. A linear quadratic model is valid from large dose per fraction down to dose per fraction of 2 Gy. Experimental studies on animals and clinical studies on the spinal cord tolerance have shown incidences of myelopathy at doses lower than 50 Gy. The α/β value of the linear quadratic model have been lower for low doses per fraction, indicating a sparing effect of altered fractionation for spinal cord myelitis. Animal data, clinical and radiobiological explanations suggest limitation of the radiobiological models. Further data suggest that one must not assume the spinal cord to have a greater tolerance at doses per fraction below the conventional dose per fraction of 2 Gy.

Get Citation
About this article
Title

The effect of altered fractionation schedule on the spinal cord response: radiobiological considerations

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 7, No 1 (2002)

Pages

27-35

Published online

2002-01-01

DOI

10.1016/S1507-1367(02)70977-2

Bibliographic record

Rep Pract Oncol Radiother 2002;7(1):27-35.

Authors

Sanjay S. Supe
K.M. Ganesh
J. Velmurugan
B.S. Rana
B.N. Sankar

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