open access

Vol 10, No 3 (2017)
Przypadki kliniczne
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Effectiveness of treatment of cryoglobulinemic glomerulonephritis with rituximab and plasmapheresis after obtaining a sustained response to interferon-free antiviral therapy in chronic hepatitis C

Marek Muszytowski1, Joanna Zawadzka1, Anna Badurek2, Leszek Jułga1
Forum Nefrologiczne 2017;10(3):186-190.
Affiliations
  1. Oddział Kliniczny Nefrologii, Diabetologii i Chorób Wewnętrznych Wojewódzki Szpital Zespolony im. L. Rydygiera, Św. Józefa 53–59, 87–100 Toruń, Poland
  2. Oddział Hepatologiczny, Wojewódzki Szpital Zespolony w Toruniu

open access

Vol 10, No 3 (2017)
Przypadki kliniczne

Abstract

Contemporary treatment of chronic hepatitis C lasts long, it is difficult and very expensive. Introduction of new antiviral drugs has significantly improved outcomes of the therapy, including patients with deteriorated kidney function. A part of the individuals with HCV infection may develop glomerulonephritis and nephrotic syndrome. Mixed cryoglobulinemia type II, which is found in almost half of the patients with hepatitis C, can be an independent factor leading to kidney injury. We present the case of 39 years old female, who developed nephrotic syndrome and kidney failure in the course of cryoglobulinemic glomerulopathy, after completing antiviral interferon-free therapy. There was introduced associated treatment of steroids, rituximab and plasma exchange, which appeared to be successful.

Abstract

Contemporary treatment of chronic hepatitis C lasts long, it is difficult and very expensive. Introduction of new antiviral drugs has significantly improved outcomes of the therapy, including patients with deteriorated kidney function. A part of the individuals with HCV infection may develop glomerulonephritis and nephrotic syndrome. Mixed cryoglobulinemia type II, which is found in almost half of the patients with hepatitis C, can be an independent factor leading to kidney injury. We present the case of 39 years old female, who developed nephrotic syndrome and kidney failure in the course of cryoglobulinemic glomerulopathy, after completing antiviral interferon-free therapy. There was introduced associated treatment of steroids, rituximab and plasma exchange, which appeared to be successful.

Get Citation

Keywords

membranoproliferative glomerulonephritis; cryoglobulin; rituximab; plasmapheresis; interferon-free therapy; HCV infection

About this article
Title

Effectiveness of treatment of cryoglobulinemic glomerulonephritis with rituximab and plasmapheresis after obtaining a sustained response to interferon-free antiviral therapy in chronic hepatitis C

Journal

Renal Disease and Transplantation Forum

Issue

Vol 10, No 3 (2017)

Pages

186-190

Bibliographic record

Forum Nefrologiczne 2017;10(3):186-190.

Keywords

membranoproliferative glomerulonephritis
cryoglobulin
rituximab
plasmapheresis
interferon-free therapy
HCV infection

Authors

Marek Muszytowski
Joanna Zawadzka
Anna Badurek
Leszek Jułga

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