open access

Vol 14, No 1 (2017)
Review paper
Published online: 2017-03-01
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Deep brain stimulation as a method of treatment in treatment-resistant depression in bipolar disorder: neuroimaging and clinical trials review

Adrian Andrzej Chrobak, Weronika Ewa Janeczko, Marcin Siwek, Dominika Dudek
Psychiatria 2017;14(1):40-46.

open access

Vol 14, No 1 (2017)
Prace poglądowe - nadesłane
Published online: 2017-03-01

Abstract

Bipolar disorder (BD) — psychiatric disorder characterized by at least one manic or hypomanic state and recurrent episodes of depression, is one of the main causes of disability among young adults. Depression — dominant in the course of BD is particularly prone to be treatment resistant. A new experimental treatment for refractory depression in the course of bipolar disorder is deep brain stimulation (DBS), associated with a single neurosurgical low – risk procedure, causes immediate antidepressant effect. Neuroimaging studies have shown sIMFB (supero-lateral branch of the medial forebrain bundle) as the most reactive for deep brain stimulation. Further studies on stimulating sIMFB carried out in the selected groups of treatment-resistant depressive patients with BD are needed.

Abstract

Bipolar disorder (BD) — psychiatric disorder characterized by at least one manic or hypomanic state and recurrent episodes of depression, is one of the main causes of disability among young adults. Depression — dominant in the course of BD is particularly prone to be treatment resistant. A new experimental treatment for refractory depression in the course of bipolar disorder is deep brain stimulation (DBS), associated with a single neurosurgical low – risk procedure, causes immediate antidepressant effect. Neuroimaging studies have shown sIMFB (supero-lateral branch of the medial forebrain bundle) as the most reactive for deep brain stimulation. Further studies on stimulating sIMFB carried out in the selected groups of treatment-resistant depressive patients with BD are needed.

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Keywords

deep brain stimulation, bipolar disorder, treatment-resistant depression, refractory depression

About this article
Title

Deep brain stimulation as a method of treatment in treatment-resistant depression in bipolar disorder: neuroimaging and clinical trials review

Journal

Psychiatria (Psychiatry)

Issue

Vol 14, No 1 (2017)

Article type

Review paper

Pages

40-46

Published online

2017-03-01

Bibliographic record

Psychiatria 2017;14(1):40-46.

Keywords

deep brain stimulation
bipolar disorder
treatment-resistant depression
refractory depression

Authors

Adrian Andrzej Chrobak
Weronika Ewa Janeczko
Marcin Siwek
Dominika Dudek

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