open access

Vol 3, No 4 (2006)
Other materials agreed with the Editors
Published online: 2006-12-08
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Family history of mood disorder and characteristics of major depressive disorder: A STAR*D (sequenced treatment alternatives to relieve depression) study

Andrew A. Nierenberg, Madhukar H. Trivedi, Maurizio Fava, Melanie M. Biggs Kathy Shores-Wilson, Stephen R. Wisniewski, G.K. Balasubramani, A. John Rush
Psychiatria 2006;3(4):169-179.

open access

Vol 3, No 4 (2006)
Prace oryginalne - tłumaczenia
Published online: 2006-12-08

Abstract


Introduction. Clinicians routinely ask patients with major depressive disorder (MDD) about their family history. It is unknown, however, if patients who report a positive family history differ from those who do not. This study compared the demographic and clinical features of a large cohort of treatment-seeking outpatients with nonpsychotic MDD who reported that they did or did not have at least one firstdegree relative who had either MDD or bipolar disorder.
Methods. Subjects were recruited for the STAR*D multicenter trial. Differences in demographic and clinical features for patients with and without a family history of mood disorders were assessed after correcting for age, sex, race, and ethnicity.
Results. Patients with a family history of mood disorder (n = 2265; 56.5%) were more frequently women and had an earlier age of onset of depression, as compared to those without such a history (n = 1740; 43.5%). No meaningful differences were found in depressive symptoms, severity, recurrence, depressive subtype, or daily function.
Conclusions. Women were twice as likely as men to report a positive family history of mood disorder, and a positive family history was associated with younger age of onset of MDD in the proband. Consistent with prior research, early age of onset appears to define a familial and, by extension, genetic subtype of major depressive disorder.

Abstract


Introduction. Clinicians routinely ask patients with major depressive disorder (MDD) about their family history. It is unknown, however, if patients who report a positive family history differ from those who do not. This study compared the demographic and clinical features of a large cohort of treatment-seeking outpatients with nonpsychotic MDD who reported that they did or did not have at least one firstdegree relative who had either MDD or bipolar disorder.
Methods. Subjects were recruited for the STAR*D multicenter trial. Differences in demographic and clinical features for patients with and without a family history of mood disorders were assessed after correcting for age, sex, race, and ethnicity.
Results. Patients with a family history of mood disorder (n = 2265; 56.5%) were more frequently women and had an earlier age of onset of depression, as compared to those without such a history (n = 1740; 43.5%). No meaningful differences were found in depressive symptoms, severity, recurrence, depressive subtype, or daily function.
Conclusions. Women were twice as likely as men to report a positive family history of mood disorder, and a positive family history was associated with younger age of onset of MDD in the proband. Consistent with prior research, early age of onset appears to define a familial and, by extension, genetic subtype of major depressive disorder.
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Keywords

family; history; major depressive disorder

About this article
Title

Family history of mood disorder and characteristics of major depressive disorder: A STAR*D (sequenced treatment alternatives to relieve depression) study

Journal

Psychiatria (Psychiatry)

Issue

Vol 3, No 4 (2006)

Article type

Other materials agreed with the Editors

Pages

169-179

Published online

2006-12-08

Bibliographic record

Psychiatria 2006;3(4):169-179.

Keywords

family
history
major depressive disorder

Authors

Andrew A. Nierenberg
Madhukar H. Trivedi
Maurizio Fava
Melanie M. Biggs Kathy Shores-Wilson
Stephen R. Wisniewski
G.K. Balasubramani
A. John Rush

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