open access

Vol 5, No 2 (2008)
Review paper
Published online: 2008-05-30
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Lithium salts - mechanisms of action

Krzysztof Pietruczuk, Jacek M. Witkowski
Psychiatria 2008;5(2):51-57.

open access

Vol 5, No 2 (2008)
Prace poglądowe - nadesłane
Published online: 2008-05-30

Abstract

In spite of the fact that lithium is presently still useful in the treatment of bipolar disorder, cellular mechanisms of its action are not fully understood. Several principal targets of lithium salts action have been identified: cytoprotective and proapoptotic proteins, inositol, cAMP, GSK-3, glutamate, GABA, PKC. In this way lithium is able to regulate neuroplasticity and induce change in axon's morphology. It appears that lithium can be useful in Alzheimer therapy as well in other neurodegenerative disorders. Lithium may also relieve side effect of cranial irradiation (for example: neurocognitive deficit) and may have beneficial effect on depressive behavior induced by mild traumatic brain injury.

Abstract

In spite of the fact that lithium is presently still useful in the treatment of bipolar disorder, cellular mechanisms of its action are not fully understood. Several principal targets of lithium salts action have been identified: cytoprotective and proapoptotic proteins, inositol, cAMP, GSK-3, glutamate, GABA, PKC. In this way lithium is able to regulate neuroplasticity and induce change in axon's morphology. It appears that lithium can be useful in Alzheimer therapy as well in other neurodegenerative disorders. Lithium may also relieve side effect of cranial irradiation (for example: neurocognitive deficit) and may have beneficial effect on depressive behavior induced by mild traumatic brain injury.
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Keywords

lithium; cytoprotection; neuroplasticity

About this article
Title

Lithium salts - mechanisms of action

Journal

Psychiatria (Psychiatry)

Issue

Vol 5, No 2 (2008)

Article type

Review paper

Pages

51-57

Published online

2008-05-30

Bibliographic record

Psychiatria 2008;5(2):51-57.

Keywords

lithium
cytoprotection
neuroplasticity

Authors

Krzysztof Pietruczuk
Jacek M. Witkowski

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