open access
Gastrointestinal autonomic nerve tumour — report of a case of GANT that developed as a secondary cancer in a neuroblastoma survivor
Affiliations- Uniwersytet Medyczny w Poznaniu, Fredry 10, Poznan, Poland
open access
Abstract
Gastrointestinal autonomic nerve tumours (GANT) are rare stromal tumours of the gastrointestinal tract
and retroperitoneum in adults; they are very uncommon among children. In the literature there are no
data about the occurrence of GANTs after neuroblastoma. The authors report a case of 12-year-old girl,
previously treated for neuroblastoma, who presented to the emergency room with symptoms of acute
abdomen. She developed intussusception caused by a tumour, which was subsequently diagnosed as
a GANT of the colon. No metastatic lesions were found. Surgery and subtotal resection of the colon were
performed. During 30 months of follow-up she had no signs of recurrence. To conclude, in cancer survivors
presenting to the emergency room with acute symptoms, recurrent or new cancer should always be
considered in the differential diagnosis.
Abstract
Gastrointestinal autonomic nerve tumours (GANT) are rare stromal tumours of the gastrointestinal tract
and retroperitoneum in adults; they are very uncommon among children. In the literature there are no
data about the occurrence of GANTs after neuroblastoma. The authors report a case of 12-year-old girl,
previously treated for neuroblastoma, who presented to the emergency room with symptoms of acute
abdomen. She developed intussusception caused by a tumour, which was subsequently diagnosed as
a GANT of the colon. No metastatic lesions were found. Surgery and subtotal resection of the colon were
performed. During 30 months of follow-up she had no signs of recurrence. To conclude, in cancer survivors
presenting to the emergency room with acute symptoms, recurrent or new cancer should always be
considered in the differential diagnosis.
Keywords
gastrointestinal autonomic nerve tumour (GANT), gastrointestinal stromal tumour (GIST), intussusception, c-kit, neuroblastoma
About this articleTitle
Gastrointestinal autonomic nerve tumour — report of a case of GANT that developed as a secondary cancer in a neuroblastoma survivor
Journal
Palliative Medicine in Practice
Issue
Article type
Case report
Pages
255-258
Published online
2020-01-03
Page views
778
Article views/downloads
625
DOI
Bibliographic record
Palliat Med Pract 2019;13(4):255-258.
Keywords
gastrointestinal autonomic nerve tumour (GANT)
gastrointestinal stromal tumour (GIST)
intussusception
c-kit
neuroblastoma
Authors
Ewelina Gowin
Katarzyna Jończyk-Potoczna
Jerzy Harasymczuk
Danuta Januszkiewicz-Lewandowska
References (13)- Yantiss RK, Rosenberg AE, Sarran L, et al. Multiple gastrointestinal stromal tumors in type I neurofibromatosis: a pathologic and molecular study. Mod Pathol. 2005; 18(4): 475–484.
- Kaneko M, Tsuchida Y, Uchino J, et al. Treatment results of advanced neuroblastoma with the first Japanese study group protocol. Study Group of Japan for Treatment of Advanced Neuroblastoma. J Pediatr Hematol Oncol. 1999; 21(3): 190–197.
- Herrera GA, Pinto de Moraes H, Grizzle WE, et al. Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma). Light and electron microscopic study confirming the origin of the neoplasm. Dig Dis Sci. 1984; 29(3): 275–284.
- Hayashi Y, Okazaki T, Yamataka A, et al. Gastrointestinal stromal tumor in a child and review of the literature. Pediatr Surg Int. 2005; 21(11): 914–917.
- Benesch M, Wardelmann E, Ferrari A, et al. Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature. Pediatr Blood Cancer. 2009; 53(7): 1171–1179.
- Marjanovic Z, Slavkovic A, Krstic M, et al. Surgical treatment of gastrointestinal autonomic nerve tumors (GANT) in children-2 case reports. Open Medicine. 2011; 6(4).
- Bethel CA, Bhattacharyya N, Hutchinson C, et al. Alimentary tract malignancies in children. J Pediatr Surg. 1997; 32(7): 1004–8; discussion 1008.
- Li P, Wei J, West AB, et al. Epithelioid gastrointestinal stromal tumor of the stomach with liver metastases in a 12-year-old girl: aspiration cytology and molecular study. Pediatr Dev Pathol. 2002; 5(4): 386–394.
- Thalheimer A, Schlemmer M, Bueter M, et al. Familial gastrointestinal stromal tumors caused by the novel KIT exon 17 germline mutation N822Y. Am J Surg Pathol. 2008; 32(10): 1560–1565.
- Johnston DL, Olson JM, Benjamin DR. Gastrointestinal stromal tumor in a patient with previous neuroblastoma. J Pediatr Hematol Oncol. 2001; 23(4): 255–256.
- Rueda O, Escribano J, Vicente JM, et al. Gastrointestinal autonomic nerve tumors (plexosarcomas). is A radiological diagnosis possible? Eur Radiol. 1998; 8(3): 458–460.
- Wu SS, Buchmiller TL, Close P, et al. Congenital gastrointestinal pacemaker cell tumor. Arch Pathol Lab Med. 1999; 123(9): 842–845.
- Terada R, Ito S, Akama F, et al. Clinical and histopathological features of colonic stromal tumor in a child. J Gastroenterol. 2000; 35(6): 456–459.
