Vol 17, No 2 (2021)
Case report
Published online: 2020-11-12
Lung ultrasonography in a patient with disseminated melanoma treated with nivolumab
Oncol Clin Pract 2021;17(2):85-88.
Abstract
A number of complications after oncological therapy increase with the number of patients who receive the treatment. The diagnostic process might be complicated and requires the use of multimodality imaging to rule out other causes. The immune-related adverse events (irAE) due to nivolumab — as myocarditis and pneumonitis are uncommon but potentially life-threatening. We present a case of a patient who developed both of them in a short-time interval.
Keywords: lung ultrasonographymelanomanivolumabside effectspneumonitispulmonary toxicity
References
- Rogiers A, Boekhout A, Schwarze JK, et al. Long-Term survival, quality of life, and psychosocial outcomes in advanced melanoma patients treated with immune checkpoint inhibitors. J Oncol. 2019; 2019: 5269062.
- Brahmer JR, Lacchetti C, Schneider BJ, et al. National Comprehensive Cancer Network. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2018; 36(17): 1714–1768.
- Nishino M, Giobbie-Hurder A, Hatabu H, et al. Incidence of programmed cell death 1 inhibitor-related pneumonitis in patients with advanced cancer: a systematic review and meta-analysis. JAMA Oncol. 2016; 2(12): 1607–1616.
- Lichtenstein DA. BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill. Chest. 2015; 147(6): 1659–1670.
- Inglis AJ, Nalos M, Sue KH, et al. Bedside lung ultrasound, mobile radiography and physical examination: a comparative analysis of diagnostic tools in the critically ill. Crit Care Resusc. 2016; 18(2): 124.
- Mojoli F, Bouhemad B, Mongodi S, et al. Lung ultrasound for critically III patients. Am J Respir Crit Care Med. 2019; 199(6): 701–714.