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Vol 14, No 3 (2018)
Guidelines / Expert consensus
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Bone sarcomas

Editors: Piotr Rutkowski, Tomasz Świtaj
DOI: 10.5603/OCP.2018.0018
Oncol Clin Pract 2018;14(3):115-128.

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Vol 14, No 3 (2018)


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Bone sarcomas


Oncology in Clinical Practice


Vol 14, No 3 (2018)

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Guidelines / Expert consensus



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Oncol Clin Pract 2018;14(3):115-128.


Editors: Piotr Rutkowski
Tomasz Świtaj

References (50)
  1. Lin PP, Patel S. Bone sarcoma. Springer 2013.
  2. Świtaj T, Nowecki ZI. Mięsaki kości. In: Krzakowski M, Potemski P, Warzocha K. ed. W Onkologia kliniczna. Viamedica, Gdańsk 2015.
  3. Kalczyk J. Epidemiologia nowotworów dziecięcych. In: Kalczyk J. ed. Wprowadzenie do onkologii i hematologii dziecięcej. Kowalczyk J (red), CMKP, Warszawa 2011.
  4. Woźniak W. Pierwotne złośliwe nowotwory kości. In: Chybicka A, Sawicz-Birkowska K. ed. Onkologia i Hematologia Dziecięca. PZWL, Warszawa 2008: Warszawa.
  5. Grzesiakowska U. Radiologiczny atlas guzów kości. Medipage 2011.
  6. NCCN Clinical Practice Guidelines in Oncology. 2016.
  7. ESMO/European Sarcoma Network Working Group. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014; 25 Suppl 3: iii113–iii123.
  8. Fletcher CD, Bridge JA. WHO Classification of Tumours of Soft Tissue and Bone. IARC, Lyon 2013.
  9. Edge S, Byrd DR, Compton CC, et al. AJCC Cancer Staging Manual. Springer. 2011.
  10. Gerrand C, Athanasou N, Brennan B, et al. British Sarcoma Group. UK guidelines for the management of bone sarcomas. Clin Sarcoma Res. 2016; 4(6:7).
  11. Huvos AG. Bone Tumours. Diagnosis, treatment and prognosis. 2nd edition, 1991. -Bone-forming tumours. : malignant.
  12. Bacci G, Picci P, Ruggieri P. Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. Cancer. 1990; 65: 2539–2553.
  13. Collins M, Wilhelm M, Conyers R, et al. Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis. J Clin Oncol. 2013; 31(18): 2303–2312.
  14. Anninga JK, Gelderblom H, Fiocco M, et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011; 47(16): 2431–2445.
  15. Eilber F, Giuliano A, Eckardt J, et al. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol. 1987; 5(1): 21–26.
  16. Ferrari S, Smeland S, Mercuri M, et al. Italian and Scandinavian Sarcoma Groups. Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. J Clin Oncol. 2005; 23(34): 8845–8852.
  17. Bielack SS, Kempf-Bielack B, Delling G, et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 2002; 20(3): 776–790.
  18. Goorin AM, Harris MB, Bernstein M, et al. Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol. 2002; 20(2): 426–433.
  19. Navid F, Willert JR, McCarville MB, et al. Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer. 2008; 113(2): 419–425.
  20. Souhami RL, Craft AW, Van der Eijken JW, et al. Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup. Lancet. 1997; 350(9082): 911–917.
  21. Marina NM, Smeland S, Bielack SS, et al. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol. 2016; 17(10): 1396–1408.
  22. Meyers PA, Schwartz CL, Krailo MD, et al. Children's Oncology Group. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. J Clin Oncol. 2008; 26(4): 633–638.
  23. Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol. 2000; 18(17): 3108–3114.
  24. Nesbit ME, Gehan EA, Burgert EO, et al. Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study. J Clin Oncol. 1990; 8(10): 1664–1674.
  25. Miser JS, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003; 348(8): 694–701.
  26. Paulussen M, Craft AW, Lewis I, et al. European Intergroup Cooperative Ewing's Sarcoma Study-92. Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients. J Clin Oncol. 2008; 26(27): 4385–4393.
  27. Le Deley MC, Paulussen M, Lewis I, et al. Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. J Clin Oncol. 2014; 32(23): 2440–2448.
  28. Denbo JW, Shannon Orr W, Wu Y, et al. Timing of surgery and the role of adjuvant radiotherapy in ewing sarcoma of the chest wall: a single-institution experience. Ann Surg Oncol. 2012; 19(12): 3809–3815.
  29. Schuck A, Ahrens S, Paulussen M, et al. Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Intl J Radiat Oncol Biol Phys. 2003; 55(1): 168–177.
  30. Bacci G, Palmerini E, Staals EL, et al. Ewing's sarcoma family tumors of the humerus: outcome of patients treated with radiotherapy, surgery or surgery and adjuvant radiotherapy. Radiother Oncol. 2009; 93(2): 383–387.
  31. Ladenstein R, Pötschger U, Le Deley MC, et al. Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial. J Clin Oncol. 2010; 28(20): 3284–3291.
  32. Schuck A, Hofmann J, Rübe C, et al. Radiotherapy in Ewing's sarcoma and PNET of the chest wall: results of the trials CESS 81, CESS 86 and EICESS 92. Int J Radiat Oncol Biol Phys. 1998; 42(5): 1001–1006.
  33. Raciborska A, Bilska K, Drabko K, et al. Vincristine, irinotecan, and temozolomide in patients with relapsed and refractory Ewing sarcoma. Pediatr Blood Cancer. 2013; 60(10): 1621–1625.
  34. Kim S, Ott HC, Wright CD, et al. Pulmonary resection of metastatic sarcoma: prognostic factors associated with improved outcomes. Ann Thorac Surg. 2011; 92(5): 1780–6; discussion 1786.
  35. Briccoli A, Rocca M, Salone M, et al. High grade osteosarcoma of the extremities metastatic to the lung: long-term results in 323 patients treated combining surgery and chemotherapy, 1985-2005. Surg Oncol. 2010; 19(4): 193–199.
  36. Whelan JS, Burcombe RJ, Janinis J, et al. A systematic review of the role of pulmonary irradiation in the management of primary bone tumours. Ann Oncol. 2002; 13(1): 23–30.
  37. Raciborska A, Bilska K, Rychłowska-Pruszyńska M, et al. Management and follow-up of Ewing sarcoma patients with isolated lung metastases. J Pediatr Surg. 2016; 51(7): 1067–1071.
  38. Weber DC, Rutz HP, Pedroni ES, et al. Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of the skull base: the Paul Scherrer Institut experience. Int J Radiat Oncol Biol Phys. 2005; 63(2): 401–409.
  39. Igaki H, Tokuuye K, Okumura T, et al. Clinical results of proton beam therapy for skull base chordoma. Int J Radiat Oncol Biol Phys. 2004; 60(4): 1120–1126.
  40. Noël G, Feuvret L, Calugaru V, et al. Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol. 2005; 44(7): 700–708.
  41. Ares C, Hug EB, Lomax AJ, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 2009; 75(4): 1111–1118.
  42. DeLaney TF, Liebsch NJ, Pedlow FX, et al. Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas. Int J Radiat Oncol Biol Phys. 2009; 74(3): 732–739.
  43. Rutz HP, Weber DC, Sugahara S, et al. Extracranial chordoma: Outcome in patients treated with function-preserving surgery followed by spot-scanning proton beam irradiation. Int J Radiat Oncol Biol Phys. 2007; 67(2): 512–520.
  44. Zabel-du Bois A, Nikoghosyan A, Schwahofer A, et al. Intensity modulated radiotherapy in the management of sacral chordoma in primary versus recurrent disease. Radiother Oncol. 2010; 97(3): 408–412.
  45. Stacchiotti S, Sommer J. Chordoma Global Consensus Group. Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol. 2015; 16(2): e71–e83.
  46. Agencja Oceny Technologii Medycznych i Taryfikacji. Rekomendacja nr 85/2015 z dnia 29 października 2015 r. Prezesa Agencji Oceny Technologii Medycznych i Taryfikacji w sprawie zakwalifikowania świadczenia opieki zdrowotnej „Radioterapia protonowa nowotworów zlokalizowanych poza narządem wzroku” jako świadczenia gwarantowanego z zakresu leczenia szpitalnego.
  47. Ruka W, Rutkowski P, Morysiński T, et al. The megavoltage radiation therapy in treatment of patients with advanced or difficult giant cell tumors of bone. Int J Radiat Oncol Biol Phys. 2010; 78(2): 494–498.
  48. Chawla S, Henshaw R, Seeger L, et al. Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study. Lancet Oncol. 2013; 14(9): 901–908.
  49. Rutkowski P, Ferrari S, Grimer RJ, et al. Surgical downstaging in an open-label phase II trial of denosumab in patients with giant cell tumor of bone. Ann Surg Oncol. 2015; 22(9): 2860–2868.
  50. Drabko K, Raciborska A, Bilska K, et al. Consolidation of first-line therapy with busulphan and melphalan, and autologous stem cell rescue in children with Ewing's sarcoma. Bone Marrow Transplant. 2012; 47(12): 1530–1534.


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