Vol 13, No 1 (2017)
Case report
Published online: 2017-07-21
Do we apply a personalised lung cancer therapy? Use of molecular tests in scheduling a multilineage treatment in a patient with lung adenocarcinoma
DOI: 10.5603/OCP.2017.0004
Oncol Clin Pract 2017;13(1):24-29.
Abstract
Molecularly targeted therapies, which can be used in genetically selected patients, play an increasing role in the multidisciplinary approach to the treatment of lung cancer. Treatment personalisation extends the scope of therapy, prolongs survival of patients and decreases the risk of life-threatening side effects. In this report, we present the diagnostic and therapeutic history of a 57-year-old male with lung adenocarcinoma and activating EGFR gene mutation. The whole therapeutic approach involved a diagnostic segmentectomy, cytoreductive surgery of the primary tumour, and a palliative hemipelvectomy of metastases in the right hip joint followed by adjuvant radiotherapy as well as six lines of systemic treatment based on standard cytostatics and novel personalised agents. Regardless of a patient’s good performance status and relatively good tolerance of the treatment, futile continuation of the therapy despite the lack of a longer stabilisation of the disease remains questionable.
Keywords: lung adenocarcinomachemotherapymolecularly targeted therapyimmunotherapy
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