open access

Vol 13, No 1 (2017)
Review paper
Published online: 2017-07-21
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Olaratumab (LARTRUVO®) as a new therapeutic option in the treatment of patients with advanced soft tissue sarcomas

Paweł Rogala1, Piotr Rutkowski1
DOI: 10.5603/OCP.2017.0001
·
Oncol Clin Pract 2017;13(1):1-7.
Affiliations
  1. Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute — Oncology Centre, Warsaw, Poland

open access

Vol 13, No 1 (2017)
REVIEW ARTICLES
Published online: 2017-07-21

Abstract

Olaratumab is a newly approved human monoclonal IgG1 antibody against platelet-derived growth factor alpha (PDGFR-α). In a relatively small, randomised phase 2 trial the drug given in combination with doxorubicin produced an overall survival improvement in patients with unresectable and/or metastatic soft tissue sarcomas. Further studies are necessary to establish the role of this agent in the treatment of advanced sarcomas. In this paper the current clinical data on olaratumab are presented.

Abstract

Olaratumab is a newly approved human monoclonal IgG1 antibody against platelet-derived growth factor alpha (PDGFR-α). In a relatively small, randomised phase 2 trial the drug given in combination with doxorubicin produced an overall survival improvement in patients with unresectable and/or metastatic soft tissue sarcomas. Further studies are necessary to establish the role of this agent in the treatment of advanced sarcomas. In this paper the current clinical data on olaratumab are presented.

Get Citation

Keywords

olaratumab, doxorubicin, soft tissue sarcoma

About this article
Title

Olaratumab (LARTRUVO®) as a new therapeutic option in the treatment of patients with advanced soft tissue sarcomas

Journal

Oncology in Clinical Practice

Issue

Vol 13, No 1 (2017)

Article type

Review paper

Pages

1-7

Published online

2017-07-21

DOI

10.5603/OCP.2017.0001

Bibliographic record

Oncol Clin Pract 2017;13(1):1-7.

Keywords

olaratumab
doxorubicin
soft tissue sarcoma

Authors

Paweł Rogala
Piotr Rutkowski

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