open access

Vol 1, No 2 (2005)
Review paper
Published online: 2005-06-08
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Postoperative adjuvant chemotherapy in non-small-cell lung cancer - review of clinical trials with randomization

Małgorzata Ploch-Glapińska, Jolanta Zapędowska, Maciej Krzakowski
Onkol. Prak. Klin 2005;1(2):63-71.

open access

Vol 1, No 2 (2005)
REVIEW ARTICLES
Published online: 2005-06-08

Abstract

Given the unsatisfactory prognosis for patients with even completely resected early-stage non-small-cell lung cancer (NSCLC), the concept of adjuvant chemotherapy appears justified. However, the results of early clinical trials evaluating adjuvant chemotherapy in NSCLC are mixed. A meta-analysis published in 1995 showed a moderate reduction in the risk of deaths with cisplatin-based chemotherapy given postoperatively, but the difference did not reach statistical significance. Four recent randomised trials demonstrated a statistically significant survival benefit for adjuvant chemotherapy with platinum-based regimens. Other studies failed to show positive results. The planned meta-analysis of recent trials is awaited mainly to identify more precisely best candidates for adjuvant chemotherapy in resected NSCLC.

Abstract

Given the unsatisfactory prognosis for patients with even completely resected early-stage non-small-cell lung cancer (NSCLC), the concept of adjuvant chemotherapy appears justified. However, the results of early clinical trials evaluating adjuvant chemotherapy in NSCLC are mixed. A meta-analysis published in 1995 showed a moderate reduction in the risk of deaths with cisplatin-based chemotherapy given postoperatively, but the difference did not reach statistical significance. Four recent randomised trials demonstrated a statistically significant survival benefit for adjuvant chemotherapy with platinum-based regimens. Other studies failed to show positive results. The planned meta-analysis of recent trials is awaited mainly to identify more precisely best candidates for adjuvant chemotherapy in resected NSCLC.
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Keywords

non-small-cell lung cancer; early stage of disease; postoperative adjuvant hemotherapy

About this article
Title

Postoperative adjuvant chemotherapy in non-small-cell lung cancer - review of clinical trials with randomization

Journal

Oncology in Clinical Practice

Issue

Vol 1, No 2 (2005)

Article type

Review paper

Pages

63-71

Published online

2005-06-08

Bibliographic record

Onkol. Prak. Klin 2005;1(2):63-71.

Keywords

non-small-cell lung cancer
early stage of disease
postoperative adjuvant hemotherapy

Authors

Małgorzata Ploch-Glapińska
Jolanta Zapędowska
Maciej Krzakowski

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