open access

Vol 1, No 3 (2005)
Review paper
Published online: 2005-09-17
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Methods of random treatment allocation in clinical trials

Agnieszka Kukowska, Rafał Dziadziuszko, Jacek Jassem
Onkol. Prak. Klin 2005;1(3):151-156.

open access

Vol 1, No 3 (2005)
REVIEW ARTICLES
Published online: 2005-09-17

Abstract

Increasing number of Polish doctors participate in clinical trials, therefore a basic knowledge on their methodology is essential. An important element of planning a research project is the choice of an appropriate randomization method allowing optimal assignment of patients to the study arms.
This article reviews techniques providing random treatment allocation and keeping similarity of known prognostic factors in the treatment groups. Addressed are also the advantages of maintaining central system of patient randomization and registration. Furthermore, main assumptions of the TENALEA project are presented. The aim of this project is to create a universal randomization service available for academic institutions performing clinical trials.

Abstract

Increasing number of Polish doctors participate in clinical trials, therefore a basic knowledge on their methodology is essential. An important element of planning a research project is the choice of an appropriate randomization method allowing optimal assignment of patients to the study arms.
This article reviews techniques providing random treatment allocation and keeping similarity of known prognostic factors in the treatment groups. Addressed are also the advantages of maintaining central system of patient randomization and registration. Furthermore, main assumptions of the TENALEA project are presented. The aim of this project is to create a universal randomization service available for academic institutions performing clinical trials.
Get Citation

Keywords

clinical trials; randomisation; minimisation; stratification

About this article
Title

Methods of random treatment allocation in clinical trials

Journal

Oncology in Clinical Practice

Issue

Vol 1, No 3 (2005)

Article type

Review paper

Pages

151-156

Published online

2005-09-17

Bibliographic record

Onkol. Prak. Klin 2005;1(3):151-156.

Keywords

clinical trials
randomisation
minimisation
stratification

Authors

Agnieszka Kukowska
Rafał Dziadziuszko
Jacek Jassem

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