open access

Vol 1, No 3 (2005)
Review paper
Published online: 2005-09-17
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Progress in the management of malignant pleural mesothelioma

Maciej Krzakowski
Onkol. Prak. Klin 2005;1(3):132-140.

open access

Vol 1, No 3 (2005)
REVIEW ARTICLES
Published online: 2005-09-17

Abstract

The incidence of malignant pleural mesothelioma is likely to increase over the next 10-20 years. Although relatively uncommon, it represents a challenge due to still unsatisfatory prognosis. Once diagnosis is made, many years after asbestos exposure, malignant pleural mesothelioma usually tends to remain confined to the hemithorax. However, the locoregional extent of disease is wide and curative resection is feasible very seldom. Moreover, the role of both local treatment modalities (surgery and radiotherapy) is unsettled definitely. Chemotherapy has been disappointing for years. However, very recently it has shown promising activity with the use of new generation antimetabolities. Although each single therapeutic modality has limited value, a combined approach may improve survival and quality of life. This overview is aiming to present current views on the use of different modalities in the treatment of malignant pleural mesothelioma, in particular their integration within combined management.

Abstract

The incidence of malignant pleural mesothelioma is likely to increase over the next 10-20 years. Although relatively uncommon, it represents a challenge due to still unsatisfatory prognosis. Once diagnosis is made, many years after asbestos exposure, malignant pleural mesothelioma usually tends to remain confined to the hemithorax. However, the locoregional extent of disease is wide and curative resection is feasible very seldom. Moreover, the role of both local treatment modalities (surgery and radiotherapy) is unsettled definitely. Chemotherapy has been disappointing for years. However, very recently it has shown promising activity with the use of new generation antimetabolities. Although each single therapeutic modality has limited value, a combined approach may improve survival and quality of life. This overview is aiming to present current views on the use of different modalities in the treatment of malignant pleural mesothelioma, in particular their integration within combined management.
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Keywords

malignant pleural mesothelioma; combined treatment; surgery; radiotherapy; chemotherapy

About this article
Title

Progress in the management of malignant pleural mesothelioma

Journal

Oncology in Clinical Practice

Issue

Vol 1, No 3 (2005)

Article type

Review paper

Pages

132-140

Published online

2005-09-17

Bibliographic record

Onkol. Prak. Klin 2005;1(3):132-140.

Keywords

malignant pleural mesothelioma
combined treatment
surgery
radiotherapy
chemotherapy

Authors

Maciej Krzakowski

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