open access

Vol 4, No 3 (2008)
Case report
Published online: 2008-07-03
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Coexistence of myeloma plasmocyticum and chronic myeloproliferative disease - report of two cases

Ilona Seferyńska, Izabela Kopeć, Grażyna Gadomska, Renata Maryniak, Przemysław Biliński, Krzysztof Warzocha
Onkol. Prak. Klin 2008;4(3):101-106.

open access

Vol 4, No 3 (2008)
CASE REPORT
Published online: 2008-07-03

Abstract

Coexistence of two neoplastic disorders derived from lymphoid and hematopoietic lineage is rarely described. We present two patients with initial presentation of myeloma plasmocyticum and symptoms of chronic myeloid disease in peripheral blood and bone marrow cytology. At first, the myeloid abnormalities were diagnosed as reactive due to underlying malignancy and patients were initially treated with cytotoxic drugs specific for myeloma. After completion of therapy, partial remission of myeloma was achieved but simultaneous progression of myeloid abnormalities was observed. Additional diagnostic tests were performed which allowed to establish the final diagnosis of coexistence of myeloma plasmocyticum with unclassified chronic myeloproliferative disease in the first patient and myeloma plasmocyticum with chronic myeloid leukemia in the second one. These cases illustrate diagnostic and therapeutic quandaries in course of the very rare coexistence of chronic lympho- and myeloproliferative disorders.

Abstract

Coexistence of two neoplastic disorders derived from lymphoid and hematopoietic lineage is rarely described. We present two patients with initial presentation of myeloma plasmocyticum and symptoms of chronic myeloid disease in peripheral blood and bone marrow cytology. At first, the myeloid abnormalities were diagnosed as reactive due to underlying malignancy and patients were initially treated with cytotoxic drugs specific for myeloma. After completion of therapy, partial remission of myeloma was achieved but simultaneous progression of myeloid abnormalities was observed. Additional diagnostic tests were performed which allowed to establish the final diagnosis of coexistence of myeloma plasmocyticum with unclassified chronic myeloproliferative disease in the first patient and myeloma plasmocyticum with chronic myeloid leukemia in the second one. These cases illustrate diagnostic and therapeutic quandaries in course of the very rare coexistence of chronic lympho- and myeloproliferative disorders.
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Keywords

myeloma plasmocyticum; unclassified chronic myeloproliferative disease; chronic myeloid leukemia

About this article
Title

Coexistence of myeloma plasmocyticum and chronic myeloproliferative disease - report of two cases

Journal

Oncology in Clinical Practice

Issue

Vol 4, No 3 (2008)

Article type

Case report

Pages

101-106

Published online

2008-07-03

Bibliographic record

Onkol. Prak. Klin 2008;4(3):101-106.

Keywords

myeloma plasmocyticum
unclassified chronic myeloproliferative disease
chronic myeloid leukemia

Authors

Ilona Seferyńska
Izabela Kopeć
Grażyna Gadomska
Renata Maryniak
Przemysław Biliński
Krzysztof Warzocha

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