Vol 4, No 3 (2008)
Case report
Published online: 2008-07-03
Coexistence of myeloma plasmocyticum and chronic myeloproliferative disease - report of two cases
Onkol. Prak. Klin 2008;4(3):101-106.
Abstract
Coexistence of two neoplastic disorders derived from lymphoid and hematopoietic lineage is rarely described.
We present two patients with initial presentation of myeloma plasmocyticum and symptoms of
chronic myeloid disease in peripheral blood and bone marrow cytology. At first, the myeloid abnormalities
were diagnosed as reactive due to underlying malignancy and patients were initially treated with cytotoxic
drugs specific for myeloma. After completion of therapy, partial remission of myeloma was achieved but
simultaneous progression of myeloid abnormalities was observed. Additional diagnostic tests were performed
which allowed to establish the final diagnosis of coexistence of myeloma plasmocyticum with unclassified
chronic myeloproliferative disease in the first patient and myeloma plasmocyticum with chronic
myeloid leukemia in the second one. These cases illustrate diagnostic and therapeutic quandaries in
course of the very rare coexistence of chronic lympho- and myeloproliferative disorders.
Keywords: myeloma plasmocyticumunclassified chronic myeloproliferative diseasechronic myeloid leukemia