open access

Vol 5, No 4 (2009)
Review paper
Published online: 2009-07-30
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Large cell neuroendocrine lung carcinoma - paper review

Marzena Gawkowska-Suwińska, Bogna Kłusek, Aleksander Zajusz, Wiesław Bal
Onkol. Prak. Klin 2009;5(4):141-147.

open access

Vol 5, No 4 (2009)
REVIEW ARTICLES
Published online: 2009-07-30

Abstract

Due to the fact, that large cell neuroendocrine carcinoma of the lung has been diagnosed more frequently in the recent years, it has become a significant diagnostic and therapeutic problem. However it is classified as a non-small cell lung carcinoma, its natural course more closely resembles that of small cell lung cancer. The present article outlines the basic histopathological information about this tumour, and provides the review of the current clinical references related to the treatment of patients with the large cell neuroendocrine lung carcinoma, based on which the therapeutic proposal for the treatment has been drafted.

Abstract

Due to the fact, that large cell neuroendocrine carcinoma of the lung has been diagnosed more frequently in the recent years, it has become a significant diagnostic and therapeutic problem. However it is classified as a non-small cell lung carcinoma, its natural course more closely resembles that of small cell lung cancer. The present article outlines the basic histopathological information about this tumour, and provides the review of the current clinical references related to the treatment of patients with the large cell neuroendocrine lung carcinoma, based on which the therapeutic proposal for the treatment has been drafted.
Get Citation

Keywords

large cell neuroendocrine carcinoma; chemotherapy; radiotherapy; surgery treatment

About this article
Title

Large cell neuroendocrine lung carcinoma - paper review

Journal

Oncology in Clinical Practice

Issue

Vol 5, No 4 (2009)

Article type

Review paper

Pages

141-147

Published online

2009-07-30

Bibliographic record

Onkol. Prak. Klin 2009;5(4):141-147.

Keywords

large cell neuroendocrine carcinoma
chemotherapy
radiotherapy
surgery treatment

Authors

Marzena Gawkowska-Suwińska
Bogna Kłusek
Aleksander Zajusz
Wiesław Bal

References (32)
  1. Travis WD, Linnoila RI, Tsokos MG, et al. Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases. Am J Surg Pathol. 1991; 15(6): 529–553.
  2. Gustafsson BI, Kidd M, Chan A, et al. Bronchopulmonary neuroendocrine tumors. Cancer. 2008; 113(1): 5–21.
  3. Travis W, Bramilla E, Muller-Hermelink H. World Health Organization classification of tumors. Pathology and genetics of tumors of the lung, pleura, thymus and heart. IARC, Lyon 2004.
  4. Tomashefski J, Dail D. Neoplastic lung disease. W: Dail and Hammar's pulmonary pathology. Wyd. 3. Springer Verlag, New York 2008: 366.
  5. Travis W. Neuroendocrine Lung Tumors. Pathology Case Reviews. 2006; 11(6): 235–242.
  6. Asamura H, Kameya T, Matsuno Y, et al. Neuroendocrine neoplasms of the lung: a prognostic spectrum. J Clin Oncol. 2006; 24(1): 70–76.
  7. Marchevsky AM, Gal AA, Shah S, et al. Morphometry confirms the presence of considerable nuclear size overlap between "small cells" and "large cells" in high-grade pulmonary neuroendocrine neoplasms. Am J Clin Pathol. 2001; 116(4): 466–472.
  8. Przygodzki RM, Finkelstein SD, Langer JC, et al. Analysis of p53, K-ras-2, and C-raf-1 in pulmonary neuroendocrine tumors. Correlation with histological subtype and clinical outcome. Am J Pathol. 1996; 148(5): 1531–1541.
  9. Peng WX, Sano T, Oyama T, et al. Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. Lung Cancer. 2005; 47(2): 225–233.
  10. Graziano SL, Mazid R, Newman N, et al. The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non-small-cell lung cancer. J Clin Oncol. 1989; 7(10): 1398–1406.
  11. Zandwijk N, Jassem E, Bonfer J, et al. Serum neuron-specific enolase and lactate dehydrogenase as predictive of response to chemotherapy and survival In non-smal cell lung cancer. Semin Oncol. 1992; 19(1 supl. 2): 37–43.
  12. Iyoda A, Hiroshima K, Toyozaki T, et al. Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. Cancer. 2001; 91(11): 1992–2000.
  13. Iyoda A, Hiroshima K, Nakatani Y, et al. Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. Ann Thorac Surg. 2007; 84(2): 702–707.
  14. Iyoda A, Hiroshima K, Moriya Y, et al. Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non-small cell carcinoma. J Thorac Cardiovasc Surg. 2006; 132(2): 312–315.
  15. Iyoda A, Hiroshima K, Moriya Y, et al. Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. Ann Thorac Surg. 2004; 77(6): 1891–1895.
  16. Chong S, Lee KS, Chung MJ, et al. Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings. Radiographics. 2006; 26(1): 41–57.
  17. Battafarano RJ, Fernandez FG, Ritter J, et al. Large cell neuroendocrine carcinoma: an aggressive form of non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005; 130(1): 166–172.
  18. Zacharias J, Nicholson AG, Ladas GP, et al. Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: prognosis after complete resection and systematic nodal dissection. Ann Thorac Surg. 2003; 75(2): 348–352.
  19. García-Yuste M, Matilla JM, González-Aragoneses F. Neuroendocrine tumors of the lung. Curr Opin Oncol. 2008; 20(2): 148–154.
  20. Kozuki T, Fujimoto N, Ueoka H, et al. Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. J Cancer Res Clin Oncol. 2005; 131(3): 147–151.
  21. Veronesi G, Morandi U, Alloisio M, et al. Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases. Lung Cancer. 2006; 53(1): 111–115.
  22. Takei H, Asamura H, Maeshima A, et al. Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases. J Thorac Cardiovasc Surg. 2002; 124(2): 285–292.
  23. Shepherd FA, Evans WK, Feld R, et al. Adjuvant chemotherapy following surgical resection for small-cell carcinoma of the lung. J Clin Oncol. 1988; 6(5): 832–838.
  24. Krzakowski M, Orłowski T, Roszkowski K, et al. Drobnokomórkowy rak płuca. Zalecenia diagnostyczno-terapeutyczne Polskiej Grupy Raka Płuca. Onkol Prakt Klin. 2007; 3: 1–7.
  25. Jassem J, Krzakowski M. Nowotwory płuca i opłucnej. Via Medica, Gdańsk 2008: 87–85.
  26. Iyoda A, Hiroshima K, Toyozaki T, et al. Adjuvant chemotherapy for large cell carcinoma with neuroendocrine features. Cancer. 2001; 92(5): 1108–1112.
  27. Iyoda A, Hiroshima K, Moriya Y, et al. Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. Ann Thorac Surg. 2006; 82(5): 1802–1807.
  28. Yamazaki S, Sekine I, Matsuno Y, et al. Clinical responses of large cell neuroendocrine carcinoma of the lung to cisplatin-based chemotherapy. Lung Cancer. 2005; 49(2): 217–223.
  29. Rossi G, Cavazza A, Marchioni A, et al. Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung. J Clin Oncol. 2005; 23(34): 8774–8785.
  30. Fujiwara Y, Sekine I, Tsuta K, et al. Effect of platinum combined with irinotecan or paclitaxel against large cell neuroendocrine carcinoma of the lung. Jpn J Clin Oncol. 2007; 37(7): 482–486.
  31. Reisinger I, Bohuslavitzki KH, Brenner W, et al. Somatostatin receptor scintigraphy in small-cell lung cancer: results of a multicenter study. J Nucl Med. 1998; 39(2): 224–227.
  32. Filosso PL, Ruffini E, Oliaro A, et al. Large-cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighteen cases and the efficacy of adjuvant treatment with octreotide. J Thorac Cardiovasc Surg. 2005; 129(4): 819–824.

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