Vol 6, No 4 (2010)
Review paper
Published online: 2010-12-16
Pharmacokinetics and pharmacogenetics in breast cancer patients systemic treatment
Onkol. Prak. Klin 2010;6(4):159-170.
Abstract
Pharmacogenetics is an intensively developing branch of science, which investigate the correlation between
genetic differentiation and treatment response. The purpose of pharmacogenetics is also a selection of
patients, who are the most likely to develope severe side effects.
The aim of this study is to recapitulate the pharmacogenetics and pharmacokinetics researches conducted in breast cancer patients received up to now. We concentrated mainly on polymorphisms in transporters proteins and in drug-metabolising enzymes used in cancer chemotherapy in breast cancer patients. Literature review was performed using ScienceDirect and PubMED bases. We discussed the influence of identified gene polymorphisms on development of severe toxic side effects in healthy tissues and tumor response.
The aim of this study is to recapitulate the pharmacogenetics and pharmacokinetics researches conducted in breast cancer patients received up to now. We concentrated mainly on polymorphisms in transporters proteins and in drug-metabolising enzymes used in cancer chemotherapy in breast cancer patients. Literature review was performed using ScienceDirect and PubMED bases. We discussed the influence of identified gene polymorphisms on development of severe toxic side effects in healthy tissues and tumor response.
Onkol. Prak. Klin. 2010; 6, 4: 159–170
Keywords: farmacogeneticspharmacokineticschemotherapyhormonotherapytrastuzumabbreast cancer
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