Vol 6, No 4 (2010)
Review paper
Published online: 2010-12-16
Perioperative treatment of gastric cancer
Onkol. Prak. Klin 2010;6(4):153-158.
Abstract
Gastric cancer still remains a common and highly fatal disease. Despite potentially curative resection of
stomach cancer, majority of patients die of disease relapse. Randomized study in the Western world failed
to show improvement in survival with extended lymph node dissection (D2 lymphadenectomy). The high
recurrence rate makes gastric cancer a disease difficult to cure by surgery alone. In order to improve the
survival different perioperative modalities are assessed. Results from the randomized phase III MAGIC trial
and French FFCD trial support the idea of preoperative chemotherapy. Neoadjuvant 5-fluorouracil/cisplatin
based chemotherapy is now a standard of care in many European countries for locally advanced gastric
cancer. Neoadjuvant chemoradiation still remains experimental. As against neoadjuvant chemoradiation,
adjuvant chemoradiation is considered to be a standard therapy in the USA and some European countries.
Onkol. Prak. Klin. 2010; 6, 4: 153–158
Keywords: gastric cancerperioperative treatmentchemotherapyradiotherapy
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