Vol 6, No 6 (2010)
Review paper
Published online: 2011-02-24

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Panitumumab and inhibition of the epidermal growth factor receptor signaling in the treatment of metastatic colorectal cancer

Lucjan S. Wyrwicz, Zbigniew I. Nowecki
Onkol. Prak. Klin 2010;6(6):290-300.

Abstract

Panitumumab is a human monoclonal antibody that targets epidermal growth factor receptor (EGFR) approved for the treatment of patients with metastatic colorectal cancer (mCRC). The current use of panitumumab is, however, restricted to the management of patients who have failed chemotherapy with irinotecan and oxaliplatin. The results of a phase III studies published in 2010 made it possible to demonstrate clinical benefit from using panitumumab in combination with first- or second-line chemotherapy in mCRC, at the same time confirming in prospective setting the benefits of using anti-EGFR treatments only in the group of patients without the KRAS mutation.
We present the results of these studies and discuss selected communications from ASCO 2010 and WCGI 2010 related to anti-EGFR treatment in mCRC.

Onkol. Prak. Klin. 2010; 6, 6: 290–300

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