Vol 7, No 2 (2011)
Review paper
Published online: 2011-06-22
Postoperative treatment of newly diagnosed glioblastoma multiforme in elderly patients
Onkol. Prak. Klin 2011;7(2):58-65.
Abstract
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Standard treatment
consists of maximally radical tumor excision and consecutive radiotherapy that optionally is associated with
simultaneous and adjuvant temozolomide (TMZ) chemotherapy. Survival of 65 years old and older patients
with GBM is short, and indications to long-term treatment remain controversial. The valuable alternative
for conventional fractionated radiotherapy is abbreviated irradiation. The results of some studies show
that, chemotherapy with TMZ alone may be an alternative for radiotherapy in elderly patients. Standard
therapeutic regimens are feasible in selected cases with good prognostic factors in elderly patients.
Onkol. Prak. Klin. 2011; 7, 2: 58–65
Onkol. Prak. Klin. 2011; 7, 2: 58–65
Keywords: glioblastoma multiformeelderly patientsradiotherapytemozolomide