open access

Vol 7, No 2 (2011)
REVIEW ARTICLES
Published online: 2011-06-22
Get Citation

Postoperative treatment of newly diagnosed glioblastoma multiforme in elderly patients

Dorota Kwapisz, Andrzej Kawecki, Maciej Krzakowski
Onkol. Prak. Klin 2011;7(2):58-65.

open access

Vol 7, No 2 (2011)
REVIEW ARTICLES
Published online: 2011-06-22

Abstract

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Standard treatment consists of maximally radical tumor excision and consecutive radiotherapy that optionally is associated with simultaneous and adjuvant temozolomide (TMZ) chemotherapy. Survival of 65 years old and older patients with GBM is short, and indications to long-term treatment remain controversial. The valuable alternative for conventional fractionated radiotherapy is abbreviated irradiation. The results of some studies show that, chemotherapy with TMZ alone may be an alternative for radiotherapy in elderly patients. Standard therapeutic regimens are feasible in selected cases with good prognostic factors in elderly patients.
Onkol. Prak. Klin. 2011; 7, 2: 58–65

Abstract

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Standard treatment consists of maximally radical tumor excision and consecutive radiotherapy that optionally is associated with simultaneous and adjuvant temozolomide (TMZ) chemotherapy. Survival of 65 years old and older patients with GBM is short, and indications to long-term treatment remain controversial. The valuable alternative for conventional fractionated radiotherapy is abbreviated irradiation. The results of some studies show that, chemotherapy with TMZ alone may be an alternative for radiotherapy in elderly patients. Standard therapeutic regimens are feasible in selected cases with good prognostic factors in elderly patients.
Onkol. Prak. Klin. 2011; 7, 2: 58–65
Get Citation

Keywords

glioblastoma multiforme; elderly patients; radiotherapy; temozolomide

About this article
Title

Postoperative treatment of newly diagnosed glioblastoma multiforme in elderly patients

Journal

Oncology in Clinical Practice

Issue

Vol 7, No 2 (2011)

Pages

58-65

Published online

2011-06-22

Bibliographic record

Onkol. Prak. Klin 2011;7(2):58-65.

Keywords

glioblastoma multiforme
elderly patients
radiotherapy
temozolomide

Authors

Dorota Kwapisz
Andrzej Kawecki
Maciej Krzakowski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl