open access

Vol 7, No 4 (2011)
Review paper
Published online: 2011-10-26
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The treatment interfering with EGFR in prostate cancer patients

Andrzej Deptała, Agnieszka Soborczyk, Karolina Krajewska
Onkol. Prak. Klin 2011;7(4):208-214.

open access

Vol 7, No 4 (2011)
REVIEW ARTICLES
Published online: 2011-10-26

Abstract

Treatment of advanced androgen-independent prostate cancer is disappointing, therefore a lot of attempts have been made, including various targeted therapies. One of the molecular targets is epidermal growth factor receptor (EGFR), which plays an important role in the progression of prostate cancer, especially in high proliferation, inhibition of apoptosis, increase of cellular motility, angiogenesis, cancer cell division and survival. In this manuscript, a comprehensive overview of the efficacy and safety of drugs interfering with function of EGFR, in the treatment of androgen-independent prostate cancer, is provided.
Onkol. Prak. Klin. 2011; 7, 4: 208–214

Abstract

Treatment of advanced androgen-independent prostate cancer is disappointing, therefore a lot of attempts have been made, including various targeted therapies. One of the molecular targets is epidermal growth factor receptor (EGFR), which plays an important role in the progression of prostate cancer, especially in high proliferation, inhibition of apoptosis, increase of cellular motility, angiogenesis, cancer cell division and survival. In this manuscript, a comprehensive overview of the efficacy and safety of drugs interfering with function of EGFR, in the treatment of androgen-independent prostate cancer, is provided.
Onkol. Prak. Klin. 2011; 7, 4: 208–214
Get Citation

Keywords

prostate cancer; epidermal growth factor receptor; EGFR; monoclonal antibodies; small molecule kinase inhibitors

About this article
Title

The treatment interfering with EGFR in prostate cancer patients

Journal

Oncology in Clinical Practice

Issue

Vol 7, No 4 (2011)

Article type

Review paper

Pages

208-214

Published online

2011-10-26

Bibliographic record

Onkol. Prak. Klin 2011;7(4):208-214.

Keywords

prostate cancer
epidermal growth factor receptor
EGFR
monoclonal antibodies
small molecule kinase inhibitors

Authors

Andrzej Deptała
Agnieszka Soborczyk
Karolina Krajewska

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