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Review paper
Published online: 2021-10-01
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The role of diagnostics and treatment — lung cancer with ALK rearrangement

Katarzyna Stencel12, Renata Langfort3, Rodryg Ramlau12
DOI: 10.5603/OCP.2020.0019
Affiliations
  1. Department of Oncology, Karol Marcinkowski Medical University in Poznan
  2. University Hospital of Lord’s Transfiguration, Karol Marcinkowski Medical University in Poznan
  3. Department of Pathology, National Tuberculosis and Lung Diseases Research Institute in Warsaw

open access

Ahead of print
REVIEW ARTICLES
Published online: 2021-10-01

Abstract

Lung cancer is the most common cause of cancer-related deaths both in Poland and worldwide. Recently, the incidence of lung adenocarcinoma has been increasing and currently it accounts for about 45% of all diagnosed lung cancers. Patients diagnosed with non-squamous non-small cell lung cancer (NSCLC), especially with adenocarcinoma, cancer containing adenocarcinoma component, large cell carcinoma, as well as patients with not otherwise specified (NOS) cancer may benefit from targeted therapy if molecular tests confirm the presence of activating EGFR gene mutations, ALK, ROS1 or NTRK rearrangement, or BRAF gene mutations. The ALK gene rearrangement is a positive predictive marker of tyrosine kinase inhibitors (TKIs) effectiveness, which are more effective than standard chemotherapy in this population, are associated with improving the quality of life and also indicate a different, more tolerable toxicity profile. This study presents the diagnostic sequence and registered treatment options for patients with ALK-positive NSCLC.

Abstract

Lung cancer is the most common cause of cancer-related deaths both in Poland and worldwide. Recently, the incidence of lung adenocarcinoma has been increasing and currently it accounts for about 45% of all diagnosed lung cancers. Patients diagnosed with non-squamous non-small cell lung cancer (NSCLC), especially with adenocarcinoma, cancer containing adenocarcinoma component, large cell carcinoma, as well as patients with not otherwise specified (NOS) cancer may benefit from targeted therapy if molecular tests confirm the presence of activating EGFR gene mutations, ALK, ROS1 or NTRK rearrangement, or BRAF gene mutations. The ALK gene rearrangement is a positive predictive marker of tyrosine kinase inhibitors (TKIs) effectiveness, which are more effective than standard chemotherapy in this population, are associated with improving the quality of life and also indicate a different, more tolerable toxicity profile. This study presents the diagnostic sequence and registered treatment options for patients with ALK-positive NSCLC.

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Keywords

non-small cell lung cancer; ALK-rearrangement; ALK-TKI; crizotinib; alectinib; brigatinib; ceritinib

About this article
Title

The role of diagnostics and treatment — lung cancer with ALK rearrangement

Journal

Oncology in Clinical Practice

Issue

Ahead of print

Article type

Review paper

Published online

2021-10-01

DOI

10.5603/OCP.2020.0019

Keywords

non-small cell lung cancer
ALK-rearrangement
ALK-TKI
crizotinib
alectinib
brigatinib
ceritinib

Authors

Katarzyna Stencel
Renata Langfort
Rodryg Ramlau

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