Adenoid cystic carcinoma of the lung — a case report
Abstract
Adenoid cystic carcinoma (ACC) is a malignant neoplasm that frequently originates from the salivary glands of the head and neck. The majority of pulmonary adenoid cystic carcinomas develop centrally in the trachea. Primary ACC of the lung arising from the bronchial glands is a rare disease and accounts for only 0.09‑0.2% of all primary lung neoplasms [1]. Although their growth rate is often indolent, they sometimes show aggressive biologic behaviour. Local invasion with perineural infiltrations, and lymph node and hematogenous metastases have been reported for some of these neoplasms [2]. Treatment options for advanced disease are limited. We herein report a case of a 56-year-old male patient with adenoid cystic carcinoma of the lung, who received conventional chemotherapy and endobronchial irradiation. This review focuses on the palliative therapy in the treatment of metastatic ACC.
Keywords: adenoid cystic carcinomalungchemotherapy
References
- Kawashima O, Hirai T, Kamiyoshihara M, et al. Primary adenoid cystic carcinoma in the lung: report of two cases and therapeutic considerations. Lung Cancer. 1998; 19(3): 211–217.
- Kang DY, Yoon YS, Kim HK, et al. Primary salivary gland-type lung cancer: surgical outcomes. Lung Cancer. 2011; 72(2): 250–254.
- Hu MM, Hu Y, He JB, et al. Primary adenoid cystic carcinoma of the lung: Clinicopathological features, treatment and results. Oncol Lett. 2015; 9(3): 1475–1481.
- Shimizu J, Oda M, Matsumoto I, et al. Clinicopathological study of surgically treated cases of tracheobronchial adenoid cystic carcinoma. Gen Thorac Cardiovasc Surg. 2010; 58(2): 82–86.
- Zhu F, Liu Z, Hou Y, et al. Primary salivary gland-type lung cancer: clinicopathological analysis of 88 cases from China. J Thorac Oncol. 2013; 8(12): 1578–1584.
- Togashi Y, Dobashi A, Sakata S, et al. MYB and MYBL1 in adenoid cystic carcinoma: diversity in the mode of genomic rearrangement and transcripts. Mod Pathol. 2018; 31(6): 934–946.
- Molina JR, Aubry MC, Lewis JE, et al. Primary salivary gland-type lung cancer: spectrum of clinical presentation, histopathologic and prognostic factors. Cancer. 2007; 110(10): 2253–2259.
- Lee JH, Jung EJ, Jeon K, et al. Treatment outcomes of patients with adenoid cystic carcinoma of the airway. Lung Cancer. 2011; 72(2): 244–249.
- Makarewicz R, Mross M. Radiation therapy alone in the treatment of tumours of the trachea. Lung Cancer. 1998; 20(3): 169–174.
- Boedker A, Hald A, Kristensen D. A method for selective endobronchial and endotracheal irradiation. J Thorac Cardiovasc Surg. 1982; 84(1): 59–61.
- Price JC, Percarpio B, Murphy PW, et al. Recurrent adenoid cystic carcinoma of the trachea: intraluminal radiotherapy. Otolaryngol Head Neck Surg. 1979; 87(5): 614–623.
- Allen AM, Rabin MS, Reilly JJ, et al. Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation. J Clin Oncol. 2007; 25(34): 5521–5523.