open access

Vol 15, No 6 (2019)
Review paper
Published online: 2020-01-10
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Pathomorphological assessment of tissue material after pre-operative systemic therapy (neoadjuvant therapy) in patients with breast cancer

Wojciech P Olszewski, Andrzej Marszałek
DOI: 10.5603/OCP.2019.0022
·
Oncol Clin Pract 2019;15(6):297-302.

open access

Vol 15, No 6 (2019)
REVIEW ARTICLES
Published online: 2020-01-10

Abstract

Oncological management of patients with breast cancer, with the use of pre-operative systemic therapy in the last decade presented significant increase of effectiveness. The greater the number of cases with complete or major pathomorphological response means that getting the right material for postoperative histopathological assessment is becoming more and more difficult. In addition, the demonstrated correlation between complete pathomorphological response (pCR) and long-term treatment effects (in HER2-positive and triple-negative subtypes of breast carcinoma) makes the standardisation of postoperative pathomorphological examination, both at the gross and microscopic level, a necessity. This article presents the recommended rules for the preparation of such material and the method of its reporting, corresponding to the needs of contemporary oncology.

Abstract

Oncological management of patients with breast cancer, with the use of pre-operative systemic therapy in the last decade presented significant increase of effectiveness. The greater the number of cases with complete or major pathomorphological response means that getting the right material for postoperative histopathological assessment is becoming more and more difficult. In addition, the demonstrated correlation between complete pathomorphological response (pCR) and long-term treatment effects (in HER2-positive and triple-negative subtypes of breast carcinoma) makes the standardisation of postoperative pathomorphological examination, both at the gross and microscopic level, a necessity. This article presents the recommended rules for the preparation of such material and the method of its reporting, corresponding to the needs of contemporary oncology.

Get Citation

Keywords

pathology, gross pathology, neoadjuvant therapy, pathology report

About this article
Title

Pathomorphological assessment of tissue material after pre-operative systemic therapy (neoadjuvant therapy) in patients with breast cancer

Journal

Oncology in Clinical Practice

Issue

Vol 15, No 6 (2019)

Article type

Review paper

Pages

297-302

Published online

2020-01-10

DOI

10.5603/OCP.2019.0022

Bibliographic record

Oncol Clin Pract 2019;15(6):297-302.

Keywords

pathology
gross pathology
neoadjuvant therapy
pathology report

Authors

Wojciech P Olszewski
Andrzej Marszałek

References (5)
  1. CAP Protocols (Protocol for the examination of resection specimens from patients with invasive carcinoma of the breast. Version 4.2.0.0 posted February 2019).
  2. Criscitiello C, Golshan M, Barry WT, et al. Impact of neoadjuvant chemotherapy and pathological complete response on eligibility for breast-conserving surgery in patients with early breast cancer: a meta-analysis. Eur J Cancer. 2018; 97: 1–6.
  3. Tahmassebi A, Wengert GJ, Helbich TH, et al. Impact of Machine Learning With Multiparametric Magnetic Resonance Imaging of the Breast for Early Prediction of Response to Neoadjuvant Chemotherapy and Survival Outcomes in Breast Cancer Patients. Invest Radiol. 2019; 54(2): 110–117.
  4. Bossuyt V. Processing and Reporting of Breast Specimens in the Neoadjuvant Setting. Surg Pathol Clin. 2018; 11(1): 213–230.
  5. Symman WF, Peintinger F, Hatzis C, et al. Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy. J Clin Oncol. 2007; 25(28): 4414–4422.

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