open access

Vol 15, No 2 (2019)
Review paper
Published online: 2019-05-17
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Why do we need a new BRAF-MEK inhibitor combination in melanoma?

Katarzyna Kozak, Piotr Rutkowski
DOI: 10.5603/OCP.2018.0054
·
Oncol Clin Pract 2019;15(2):115-119.

open access

Vol 15, No 2 (2019)
REVIEW ARTICLES
Published online: 2019-05-17

Abstract

Despite the increasing role of immunotherapy, BRAF/MEK inhibitor combinations have still a central role in the treatment of BRAF V600-mutant melanoma. Encorafenib-binimetinib is the third BRAF-MEK inhibitor combination approved for the metastatic melanoma with BRAF V600 mutation. Data from phase III trial demonstrated high antitumor efficacy and good tolerability of encorafenib-binimetinib. Compared to other combinations (dabrafenib-trametinib, vemurafenib-cobimetinib) the new combination showed favourable results in terms of the low rates of pyrexia and photosensitivity. Trials with triplet regimens that combine encorafenib-binimetinib with immunotherapy or a third targeted agent in an effort to overcome mechanisms of resistance to BRAF/MEK inhibition are ongoing.

Abstract

Despite the increasing role of immunotherapy, BRAF/MEK inhibitor combinations have still a central role in the treatment of BRAF V600-mutant melanoma. Encorafenib-binimetinib is the third BRAF-MEK inhibitor combination approved for the metastatic melanoma with BRAF V600 mutation. Data from phase III trial demonstrated high antitumor efficacy and good tolerability of encorafenib-binimetinib. Compared to other combinations (dabrafenib-trametinib, vemurafenib-cobimetinib) the new combination showed favourable results in terms of the low rates of pyrexia and photosensitivity. Trials with triplet regimens that combine encorafenib-binimetinib with immunotherapy or a third targeted agent in an effort to overcome mechanisms of resistance to BRAF/MEK inhibition are ongoing.
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Keywords

advanced melanoma; BRAF mutation; encorafenib; binimetinib

About this article
Title

Why do we need a new BRAF-MEK inhibitor combination in melanoma?

Journal

Oncology in Clinical Practice

Issue

Vol 15, No 2 (2019)

Article type

Review paper

Pages

115-119

Published online

2019-05-17

DOI

10.5603/OCP.2018.0054

Bibliographic record

Oncol Clin Pract 2019;15(2):115-119.

Keywords

advanced melanoma
BRAF mutation
encorafenib
binimetinib

Authors

Katarzyna Kozak
Piotr Rutkowski

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