open access

Vol 15, No 3 (2019)
Review paper
Published online: 2019-06-26
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ALK, ROS1 and EGFR next-generation tyrosine kinase inhibitors in advanced non-small-cell lung cancer

Kinga Winiarczyk, Aleksandra Piórek, Maciej Krzakowski
DOI: 10.5603/OCP.2018.0042
·
Oncol Clin Pract 2019;15(3):150-157.

open access

Vol 15, No 3 (2019)
REVIEW ARTICLES
Published online: 2019-06-26

Abstract

Non-small-cell lung cancer (NSCLC) is the most common cancer in men and the second most common in fe- males. In previous years the significance of some molecular disorders in pathogenesis NSCLC was proven and the value of targeted therapies in the treatment of patients was documented. In subjects with abnormalities of EGFR, ALK and ROS1 genes, appropriate tyrosine kinase inhibitors (TKIs) may be used. The use of these drugs in the first and second treatment lines has affected a significant improvement in the prognosis in this subgroup of patients. The article presents mechanisms of action and data on the clinical value of lorlatinib, brigatinib and dacomitinib in the treatment of patients with advanced lung of lung cancer.

Abstract

Non-small-cell lung cancer (NSCLC) is the most common cancer in men and the second most common in fe- males. In previous years the significance of some molecular disorders in pathogenesis NSCLC was proven and the value of targeted therapies in the treatment of patients was documented. In subjects with abnormalities of EGFR, ALK and ROS1 genes, appropriate tyrosine kinase inhibitors (TKIs) may be used. The use of these drugs in the first and second treatment lines has affected a significant improvement in the prognosis in this subgroup of patients. The article presents mechanisms of action and data on the clinical value of lorlatinib, brigatinib and dacomitinib in the treatment of patients with advanced lung of lung cancer.
Get Citation

Keywords

non-small-cell lung cancer; kinase inhibitors; lorlatinib; brigatinib; dacomitinib

About this article
Title

ALK, ROS1 and EGFR next-generation tyrosine kinase inhibitors in advanced non-small-cell lung cancer

Journal

Oncology in Clinical Practice

Issue

Vol 15, No 3 (2019)

Article type

Review paper

Pages

150-157

Published online

2019-06-26

DOI

10.5603/OCP.2018.0042

Bibliographic record

Oncol Clin Pract 2019;15(3):150-157.

Keywords

non-small-cell lung cancer
kinase inhibitors
lorlatinib
brigatinib
dacomitinib

Authors

Kinga Winiarczyk
Aleksandra Piórek
Maciej Krzakowski

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