Vol 14, No 6 (2018)
Guidelines / Expert consensus
Published online: 2019-03-15
Recommendations in management of head and neck sarcomas
Oncol Clin Pract 2018;14(6):295-301.
Abstract
Sarcomas of the head and neck are rare malignant tumours with incidence 2% of head and neck cancers, 30% of all sarcomas in children and 4–10% of sarcomas in adults. The most common sarcoma in children is rhabdomyosarcoma (RMS) and Ewing sarcoma (ES), in contrary in elderlies there is angiosarcoma; osteosarcoma and chondrosarcoma are the most common bone tumours in head and neck. The typical symptoms are: painless tumour in the head and neck region, difficulty with speaking, hoarseness, dysphagia, nasal obturation, or dysfunction of cranial nerves. The key point of diagnostics is magnetic resonance and computed tomography of the primary tumour. The treatment of patients with sarcoma should be carried out in referral centers, where experienced multidisciplinary team proceed the surgical removal of a primary tumour with reconstructive surgery as well as perioperative systemic therapy (in selected cases). The recommendations were developed by the Head and Neck Sarcoma Group of the Polish Registry of Bone Tumors.
Keywords: sarcomareference centermultidisciplinary treatment
References
- Kraus DH, Dubner S, Harrison LB, et al. Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas. Cancer. 1994; 74(2): 697–702.
- Hoffman HT, Robinson RA, Spiess JL, et al. Update in management of head and neck sarcoma. Curr Opin Oncol. 2004; 16(4): 333–341.
- Potter BO, Sturgis EM. Sarcomas of the head and neck. Surg Oncol Clin N Am. 2003; 12(2): 379–417.
- Peng KA, Grogan T, Wang MB. Head and neck sarcomas: analysis of the SEER database. Otolaryngol Head Neck Surg. 2014; 151(4): 627–633.
- Fletcher CDM, Chibon F, Mertens F. Undifferentiated/unclassified sarcomas. In: WHO classifiction of tumours of soft tissue and bone, 4th, , Bridge JA, Hogendoorn PCW, Mertens F (Eds), IARC, Lyon 2013. p. ; 236.
- Freedman AM, Reiman HM, Woods JE. Soft-tissue sarcomas of the head and neck. Am J Surg. 1989; 158(4): 367–372.
- Mattavelli D, Miceli R, Radaelli S, et al. Head and neck soft tissue sarcomas: prognostic factors and outcome in a series of patients treated at a single institution. Ann Oncol. 2013; 24(8): 2181–2189.
- Kartha SS, Bumpous JM. Synovial cell sarcoma: diagnosis, treatment, and outcomes. Laryngoscope. 2002; 112(11): 1979–1982.
- Mallen-St Clair J, Arshi A, Abemayor E, et al. Factors Associated With Survival in Patients With Synovial Cell Sarcoma of the Head and Neck: An Analysis of 167 Cases Using the SEER (Surveillance, Epidemiology, and End Results) Database. JAMA Otolaryngol Head Neck Surg. 2016; 142(6): 576–583.
- Daw NC, Mahmoud HH, Meyer WH, et al. Bone sarcomas of the head and neck in children: the St Jude Children's Research Hospital experience. Cancer. 2000; 88(9): 2172–2180.
- Eeles RA, Fisher C, A'Hern RP, et al. Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer. 1993; 68(1): 201–207.
- Sale KA, Wallace DI, Girod DA, et al. Radiation-induced malignancy of the head and neck. Otolaryngol Head Neck Surg. 2004; 131(5): 643–645.
- Yeang MS, Tay K, Ong WS, et al. Outcomes and prognostic factors of post-irradiation and de novo sarcomas of the head and neck: a histologically matched case-control study. Ann Surg Oncol. 2013; 20(9): 3066–3075.
- Farhood AI, Hajdu SI, Shiu MH, et al. Soft tissue sarcomas of the head and neck in adults. Am J Surg. 1990; 160(4): 365–369.
- Ketabchi A, Kalavrezos N, Newman L. Sarcomas of the head and neck: a 10-year retrospective of 25 patients to evaluate treatment modalities, function and survival. Br J Oral Maxillofac Surg. 2011; 49(2): 116–120.
- Gil Z, Patel SG, Singh B, et al. International Collaborative Study Group. Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: an international collaborative study. Cancer. 2007; 110(5): 1033–1041.
- Lilian M, Janeway G, Janeway K, et al. Sarcoma: Bone lesion. Pediatric head and neck tumors. Springer New York. 2014.
- Park JT, Roh JL, Kim SO, et al. Prognostic factors and oncological outcomes of 122 head and neck soft tissue sarcoma patients treated at a single institution. Ann Surg Oncol. 2015; 22(1): 248–255.
- Meyer JS, et al. NadelHR, Marina N. Imaging Guidelines for Children With Ewing Sarcoma and Osteosarcoma: A Report From the Children’s Oncology Group Bone Tumor Committee, Pediatr Blood Cancer. 2008; 51: 163.
- National Comprehensive Cancer Network. Bone Cancer (Version 2.2018). http://www.nccn.org/professionals/physician_gls/pdf/bone.pdf (April 9, 2018).
- O'Sullivan B, Maki RG, Agulmik M, et al. Soft tissue sarcomas of the head and neck. In: AJCC Cancer Staging Manual, 8, Amin MB, (Eds), American Joint Committee on Cancer, Chicago 2017. p. ; 503.
- Kneisl J, Rosenberg A, Anderson P, et al. Bone. AJCC Cancer Staging Manual. 2016: 471–486.
- Zagars GK, Ballo MT, Pisters PWT, et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients. Cancer. 2003; 97(10): 2530–2543.
- Affinita MC, Ferrari A, Milano GM, et al. Long-term results in children with head and neck rhabdomyosarcoma: A report from the Italian Soft Tissue Sarcoma Committee. Pediatr Blood Cancer. 2018; 65(3).
- Balm AJ, Vom Coevorden F, Bos KE, et al. Report of a symposium on diagnosis and treatment of adult soft tissue sarcomas in the head and neck. Eur J Surg Oncol. 1995; 21(3): 287–289.
- Mendenhall WM, Mendenhall CM, Werning JW, et al. Adult head and neck soft tissue sarcomas. Head Neck. 2005; 27(10): 916–922.
- Barker JL, Paulino AC, Feeney S, et al. Locoregional treatment for adult soft tissue sarcomas of the head and neck: an institutional review. Cancer J. 2003; 9(1): 49–57.
- Le Vay J, O'Sullivan B, Catton C, et al. An assessment of prognostic factors in soft-tissue sarcoma of the head and neck. Arch Otolaryngol Head Neck Surg. 1994; 120(9): 981–986.
- Jasnau S, Meyer U, Potratz J, et al. Cooperative Osteosarcoma Study Group COSS. Craniofacial osteosarcoma Experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol. 2008; 44(3): 286–294.
- Huh WW, Holsinger FC, Levy A, et al. Osteosarcoma of the jaw in children and young adults. Head Neck. 2012; 34(7): 981–984.
- DeAngelis AF, Spinou C, Tsui A, et al. Outcomes of patients with maxillofacial osteosarcoma: a review of 15 cases. J Oral Maxillofac Surg. 2012; 70(3): 734–739.
- Vogel J, Both S, Kirk M, et al. Proton therapy for pediatric head and neck malignancies. Pediatr Blood Cancer. 2018; 65(2).
- Raciborska A, Bilska K, Drabko K, et al. Validation of a multi-modal treatment protocol for Ewing sarcoma--a report from the polish pediatric oncology group. Pediatr Blood Cancer. 2014; 61(12): 2170–2174.
- Kozelsky TF, Bonner JA, Foote RL, et al. Laryngeal chondrosarcomas: the Mayo Clinic experience. J Surg Oncol. 1997; 65(4): 269–273.
- Chin OY, Dubal PM, Sheikh AB, et al. Laryngeal chondrosarcoma: A systematic review of 592 cases. Laryngoscope. 2017; 127(2): 430–439.
- Koch BB, Karnell LH, Hoffman HT, et al. National cancer database report on chondrosarcoma of the head and neck. Head Neck. 2000; 22(4): 408–425.
- Wanebo HJ, Koness RJ, MacFarlane JK, et al. Head and neck sarcoma: report of the Head and Neck Sarcoma Registry. Society of Head and Neck Surgeons Committee on Research. Head Neck. 1992; 14(1): 1–7.
- Weber RS, Benjamin RS, Peters LJ, et al. Soft tissue sarcomas of the head and neck in adolescents and adults. Am J Surg. 1986; 152(4): 386–392.
- Albores-Saavedra J, Schwartz AM, Henson DE, et al. Cutaneous angiosarcoma. Analysis of 434 cases from the Surveillance, Epidemiology, and End Results Program, 1973-2007. Ann Diagn Pathol. 2011; 15(2): 93–97.
- Lydiatt WM, Shaha AR, Shah JP. Angiosarcoma of the head and neck. Am J Surg. 1994; 168(5): 451–454.
- Fury MG, Antonescu CR, Van Zee KJ, et al. A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer J. 2005; 11(3): 241–247.
- Maddox JC, Evans HL. Angiosarcoma of skin and soft tissue: a study of forty-four cases. Cancer. 1981; 48(8): 1907–1921.
- Morrison WH, Byers RM, Garden AS, et al. Cutaneous angiosarcoma of the head and neck. A therapeutic dilemma. Cancer. 1995; 76(2): 319–327.
- Willers H, Hug EB, Spiro IJ, et al. Adult soft tissue sarcomas of the head and neck treated by radiation and surgery or radiation alone: patterns of failure and prognostic factors. Int J Radiat Oncol Biol Phys. 1995; 33(3): 585–593.
- Köhler HF, Neves RI, Brechtbühl ER, et al. Cutaneous angiosarcoma of the head and neck: report of 23 cases from a single institution. Otolaryngol Head Neck Surg. 2008; 139(4): 519–524.
- Patel SH, Hayden RE, Hinni ML, et al. Angiosarcoma of the scalp and face: the Mayo Clinic experience. JAMA Otolaryngol Head Neck Surg. 2015; 141(4): 335–340.
- Lahat G, Dhuka AR, Hallevi H, et al. Angiosarcoma: clinical and molecular insights. Ann Surg. 2010; 251(6): 1098–1106.
- Aust MR, Olsen KD, Lewis JE, et al. Angiosarcomas of the head and neck: clinical and pathologic characteristics. Ann Otol Rhinol Laryngol. 1997; 106(11): 943–951.