Vol 14, No 1 (2018)
Review paper
Published online: 2018-02-28
Dual HER2 blockade in adjuvant and neoadjuvant treatment of HER2-positive breast cancer: the role of pertuzumab
DOI: 10.5603/OCP.2018.0008
Oncol Clin Pract 2018;14(1):43-47.
Abstract
Trastuzumab and pertuzumab belong to the group of humanised IgG1 monoclonal antibodies produced using recombinant DNA technology. The synergism of action of both antibodies results from their different targets: trastuzumab binds to the IV subdomain of the HER2 receptor and blocks signals independent of the ligand, while pertuzumab binds to subdomain II of this receptor and blocks ligand-dependent signals. Adding pertuzumab to trastuzumab and chemotherapy in pre-operative (neoadjuvant) treatment of HER2-positive breast cancer patients increases complete pathological response rates without enhancing adverse reactions. It was also shown in patients with breast cancer that pCR resulting from pre-operative treatment may translate into improved survival parameters
Keywords: trastuzumabpertuzumabperioperative therapybreast cancerHER2
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