Vol 14, No 3 (2018)
Case report
Published online: 2018-06-20
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Chondrosarcoma of the maxilla: a case report and review of current literature

Łukasz Szylberg1, Adam Kowalewski1, Joanna Kowalewska1, Katarzyna Pawlak-Osińska2, Anna Kasperska1, Andrzej Marszałek3
DOI: 10.5603/OCP.2018.0021
Oncol Clin Pract 2018;14(3):160-163.

Abstract

Chondrosarcoma is a malignant mesenchymal tumour that is the second most common bone tumour after osteosarcoma. Its diagnosis is among the most difficult ones in tumour pathology. Here, we report a very unique case of chondrosarcoma in maxillary sinus. A 45-year-old woman presented with a tumour on the left side of the maxillary sinus. CT and MRI imaging showed an abnormal mass destructing surrounding tissues. The final diagnosis of chondrosarcoma could not be made for a long time due to lack of correlation between clinical and microscopic examinations. The patient underwent left subtotal maxillectomy via Weber-Ferguson incision, bilateral ethmoidectomy, sphenoidectomy, and right upper turbinectomy, and excision of nasal septum, left frontal sinus, and left exenteration of orbit. Histological changes in the small biopsy specimen may be not sufficient for definitive diagnosis. Our case shows that radiography combined with histopathology is necessary to make the final diagnosis. The presented case revealed that chondrosarcoma can be a heterogeneous tumour. Collecting tissue samples from different locations is essential for improving diagnosis and reducing diagnostic error. Combining clinical data even with uncertain microscopic examination may be a solution in borderline and complicated cases.

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References

  1. Mahajan AM, Ganvir Sm, Hazarey Vk, et al. Chondrosarcoma of the maxilla: A case report and review of literature. J Oral Maxillofac Pathol. 2013; 17(2): 269–273.
  2. Verdegaal SHM, Bovée JV, Pansuriya TC, et al. Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients. Oncologist. 2011; 16(12): 1771–1779.
  3. Bloch OG, Jian BJ, Yang I, et al. A systematic review of intracranial chondrosarcoma and survival. J Clin Neurosci. 2009; 16(12): 1547–1551.
  4. Beer-Furlan A, Balsalobre L, Vellutini EAS, et al. Endoscopic Endonasal Approach in Skull Base Chondrosarcoma Associated with Maffucci Syndrome: Case Series and Literature Review. World Neurosurg. 2016; 85: 365.e7–365.15.
  5. Bovée JV, Hogendoorn PCW, Wunder JS, et al. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer. 2010; 10(7): 481–488.
  6. Papachristou DJ, Goodman MA, Cieply K, et al. Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis. Hum Pathol. 2006; 37(7): 890–898.
  7. Awad M, Gogos AJ, Kaye AH. Skull base chondrosarcoma. J Clin Neurosci. 2016; 24: 1–5.
  8. Sathappan S, Razak HA, Loo CP. Metastatic nasal chondrosarcoma. Med J Malaysia. 2007; 62(4): 347–348.
  9. Saini R, Abd Razak NH, Ab Rahman S, et al. Chondrosarcoma of the mandible: a case report. J Can Dent Assoc. 2007; 73(2): 175–178.
  10. Robert B, Andrzej M, Paweł B. Chondrosarcoma of the maxilla-case report. Otorynolaryngologia. 2010; 9: 98–102.
  11. Kharrat S, Sahtout S, Tababi S, et al. Chondrosarcoma of sinonasal cavity: a case report and brief literature review. Tunis Med. 2010; 88(2): 122–124.
  12. Sammartino G, Marenzi G, Howard CM, et al. Chondrosarcoma of the jaw: a closer look at its management. J Oral Maxillofac Surg. 2008; 66(11): 2349–2355.
  13. Nimonkar P, Bhola N, Jadhav A, et al. Myxoid Chondrosarcoma of Maxilla in a Pediatric Patient: A Rare Case Report. Case Rep Oncol Med. 2016; 2016: 5419737.
  14. Horta M, Fernandes L, Borges A. Chondrosarcoma of the hyoid bone: an atypical site of a sarcoma of the head and the neck. BMJ Case Rep. 2015; 2015.
  15. Satomi T, Kaneko T, Abukawa H, et al. Chondrosarcoma of the maxilla extending to the pterygomandibular space: a case report and review of the literature. J Maxillofac Oral Surg. 2015; 14(Suppl 1): 133–137.
  16. Mahajan AM, Ganvir Sm, Hazarey Vk, et al. Chondrosarcoma of the maxilla: A case report and review of literature. J Oral Maxillofac Pathol. 2013; 17(2): 269–273.
  17. Unni K, Inwards C, Bridge J, Kindblohm LG. Tumor of the Bones and Joints. AFIP Atlas of Tumor Pathology 2005.
  18. Huang WC, Hu KY, Kuo KT, et al. Mesenchymal chondrosarcoma of the maxilla: Case report and clinicopathologic review. Tzu Chi Med J. 2013; 25(1): 55–57.
  19. Jaetli V, Gupta S. Mesenchymal chondrosarcoma of maxilla: a rare case report. Med Oral Patol Oral Cir Bucal. 2011; 16(4): e493–e496.
  20. Krishnamurthy A, Vaidhyanathan A, Srinivas S, et al. A fatal case of mesenchymal chondrosarcoma of the mandible. J Cancer Res Ther. 2011; 7(2): 192–194.
  21. Kedar S. Giant Chondroblastic Osteosarcoma Mandible-A Rare Case Report. Otolaryng. 2013; 03(04).